IFN-gamma R1/CD119 Antibody (24GB13660)

Name: IFN-gamma R1/CD119 Antibody (24GB13660)
Brand: Novus Biologicals
SKU: NBP3-51919
Price: 499 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-51919

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Product Specifications
Scientific Data
Applications
Flow Cytometry
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB13660

View all IFN-gamma R1/CD119 Primary Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human IFN-gamma R1/CD119 (Uniprot: P15260)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IFN-gamma R1/CD119 Antibody (24GB13660)

Immunocytochemistry/ Immunofluorescence: IFN-gamma R1/CD119 Antibody (24GB13660)[NBP3-51919] -

Immunocytochemical staining of C2C12 cells with IFN-gamma R1/CD119 antibody (1:1,000). Nuclei were stained blue with DAPI; IFN-gamma R1/CD119 was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.

Flow Cytometry: IFN-gamma R1/CD119 Antibody (24GB13660)[NBP3-51919] -

Flow cytometric analysis of IFN-gamma R1/CD119expression in C2C12 cells using IFN-gamma R1/CD119 antibody (1:1,000). Green, isotype control; red, Interferon gamma receptor 1.

Western Blot: IFN-gamma R1/CD119 Antibody (24GB13660)[NBP3-51919] -

Western blotting analysis using IFN-gamma R1/CD119 antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for IFN-gamma R1/CD119 Antibody (24GB13660)

Application

Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

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Advanced Features

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Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IFN-gamma R1/CD119

IFN gamma receptor beta is part of the receptor for interferon gamma. This class II cytokine receptor pairs with CDw119 to form the IFN gamma receptor and is an integral part of the IFN gamma signal transduction pathway. CDw119 serves as the IFN gamma binding chain and associates with the IFN gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN gamma receptor alpha and beta chains must be species matched. The IFN gamma receptor beta chain is expressed on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. It is also likely to interact with GAF. IFN gamma initiates and regulates a variety of immune responses and is required for signal transduction. Contains 2 fibronectin type III domains. Defects in IFN gamma Receptor beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), a rare condition that confers predisposition to illness caused by several mycobacteria strains.

Long Name

Interferon gamma Receptor 1

Alternate Names

CD119, IFN-gR1, IFNgammaR1, IFNGR1

Gene Symbol

IFNGR1

Additional IFN-gamma R1/CD119 Products

Product Documents for IFN-gamma R1/CD119 Antibody (24GB13660)

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Certificate of Analysis

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Product Specific Notices for IFN-gamma R1/CD119 Antibody (24GB13660)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.