IL-6R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6R alpha. IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.
Rat IL-6R alpha ELISA Kit (Colorimetric)
Novus Biologicals | Catalog # NBP2-75389
Key Product Details
Sample Type & Volume Required Per Well
Sensitivity
Assay Range
Product Specifications
Assay Type
Kit Type
Species
Specificity
Precision
Intra-Assay Precision (Precision within an assay) CV% 5.09%
Inter-Assay Precision (Precision between assays) CV% 5.43%
Recovery for Rat IL-6R alpha ELISA Kit (Colorimetric)
Recovery
Linearity
Scientific Data Images for Rat IL-6R alpha ELISA Kit (Colorimetric)
ELISA: Rat IL-6R alpha ELISA Kit (Colorimetric) [NBP2-75389] -
ELISA: Rat IL-6R alpha ELISA Kit (Colorimetric) [NBP2-75389] - Standard Curve ReferenceKit Contents for Rat IL-6R alpha ELISA Kit (Colorimetric)
- Biotinylated Detection Ab Diluent
- Concentrated Biotinylated Detection Ab (100x)
- Concentrated HRP Conjugate (100x)
- Concentrated Wash Buffer (25x)
- HRP Conjugate Diluent
- Micro ELISA Plate (Dismountable)
- Plate Sealer
- Product Manual
- Reference Standard
- Sample Diluent
- Stop Solution
- Substrate Reagent
Preparation and Storage
Shipping
Stability & Storage
Background: IL-6R alpha
Long Name
Alternate Names
Gene Symbol
Additional IL-6R alpha Products
Product Documents for Rat IL-6R alpha ELISA Kit (Colorimetric)
Certificate of Analysis
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Product Specific Notices for Rat IL-6R alpha ELISA Kit (Colorimetric)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.
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