Imipramine hydrochloride

Catalog # Availability Size / Price Qty
Imipramine hydrochloride | CAS No. 113-52-0 | Autophagy-related Compounds
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Description: Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment

Chemical Name: 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride

Purity: ≥98%

Product Details

Biological Activity

Imipramine hydrochloride is a potent tricyclic antidepressant; inhibits 5-HT and noradrenalin transporters (Ki values = 1.3-20 nM and 20-142 nM respectively). Increases autophagy, both alone and in combination with VEGF inhibitors or Temozolomide (Cat. No. 2706), to reduce the progression of glioma and slow the proliferation of other tumors. Reprograms tumor-associated macrophages from immunosuppressive to immunostimulatory via histamine receptor inhibition.

Technical Data

Soluble to 50 mM in DMSO and to 50 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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