Integrin beta 3/CD61 Antibody (rITGB3/2145) - Azide and BSA Free

Name: Integrin beta 3/CD61 Antibody (rITGB3/2145) - Azide and BSA Free
Brand: Novus Biologicals
SKU: NBP3-49448
Price: 509 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-49448

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG₁ kappa Clone # rITGB3/2145

Format

Azide and BSA Free

View all Integrin beta 3/CD61 Primary Antibodies »

Product Specifications

Immunogen

Recombinant human ITGB3 protein fragment (aa 385-490) (exact sequence is proprietary) (Uniprot: P05106)

Localization

Cell junction, Cell membrane, Cell projection, Focal adhesion, Lamellipodium membrane, Postsynaptic cell membrane, Synapse

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁ kappa

Description

Prepared in 10mM PBS WITHOUT BSA & azide at 1.0mg/ml. Also available with 0.05% BSA & 0.05% azide.

Antibody with azide - store at 2 to 8 C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous.

Scientific Data Images for Integrin beta 3/CD61 Antibody (rITGB3/2145) - Azide and BSA Free

Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody (rITGB3/2145) - Azide and BSA Free [NBP3-49448] -

Formalin-fixed, paraffin-embedded human spleen stained with Integrin beta 3/CD61 Antibody (rITGB3/2145) - Azide and BSA Free.

Applications for Integrin beta 3/CD61 Antibody (rITGB3/2145) - Azide and BSA Free

Application

Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: Integrin beta 3/CD61

Platelet membrane glycoprotein Integrin beta-3 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets. A biochemically and immunologically similar membrane glycoprotein complex is present on endothelial cells. Homology suggests that GP IIIa is a member of a family of cell-surface adhesion receptors. (1) Data provide further support for the key role of the cytoplasmic domain of the beta3 integrin in cell adhesion and suggest a potential role for the beta3C integrin subunit in modulating cell-matrix interactions (2). It has been demonstrated that the beta 3 subunit of alpha IIb beta 3 was phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Data suggest that tyrosine phosphorylation of an integrin beta subunit may be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3). be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3).

Alternate Names

CD61, GP3A, GPIIIA, INGRB3, ITGB3

Gene Symbol

ITGB3

Additional Integrin beta 3/CD61 Products

Product Documents for Integrin beta 3/CD61 Antibody (rITGB3/2145) - Azide and BSA Free

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Certificate of Analysis

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Product Specific Notices for Integrin beta 3/CD61 Antibody (rITGB3/2145) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.