Ionomycin calcium salt
Chemical Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of ionomycin as a calcium ionophore.
Liu and Hermann
Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.
Kaufmann et al.
Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils.
Elzi et al.
Am.J.Physiol.Cell Physiol., 2001;281:C350
Citations for Ionomycin calcium salt
The citations listed below are publications that use Tocris products. Selected citations for Ionomycin calcium salt include:
17 Citations: Showing 1 - 10
Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury.
Authors: Su Et al.
Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
Authors: Nieuwenhuijze Et al.
Front Immunol 2018;9:2234
Probing Internalization Effects and Biocompatibility of Ultrasmall Zirconium Metal-Organic Frameworks UiO-66 NP in U251 Glioblastoma Cancer Cells.
Authors: Arcuri Et al.
Nanomaterials (Basel) 2018;8
Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair.
Authors: Mikolajewicz Et al.
Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium.
Authors: Mihara Et al.
PLoS One 2018;13:e0206276
Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells.
Authors: Son Et al.
J Dent Res 2015;94:473
Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
Authors: Azab Et al.
PLoS One 2015;6
Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype.
Authors: Plog Et al.
PLoS One 2015;10:e0140050
Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.
Authors: Jonas Et al.
J Pharmacol Exp Ther 2015;10:e0139107
TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
Authors: Shambharkar Et al.
Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
Authors: Soltoff and Lannon
PLoS One 2013;8:e72881
Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B.
Authors: Barcomb Et al.
Mol Pharmacol 2013;84:834
Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Authors: Rojas Et al.
Mol Pharmacol 2013;83:106
Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1.
Authors: Selway Et al.
PLoS One 2012;7:e33004
TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity.
Authors: Shahidullah Et al.
Am J Physiol Cell Physiol 2012;302:C1751
A screen for regulators of survival of motor neuron protein levels.
Authors: Makhortova Et al.
Nat Chem Biol 2011;7:544
Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cells.
Authors: Ohya Et al.
J Biol Chem 2011;286:16940
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HEK293 cells were loaded with intracellular Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 40 min in dark at room temperature, washed and kept in normal tyrode for 20 min. Fura2-loaded cells were excited at 340 and 380 nm and fluorescence at 510 nm was expressed as F340/F380 ratio, as an index of cytosolic Ca2+. Ca2+ stores were depleted with 1 µM ionomycin Ca in nominally Ca2+ free-tyrode solution, resulting in cytosolic Ca2+ peak.
Elicits calcium increase, used as a positive control at the end of calcium imaging experiments.