Catalog Number: 1704
Chemical Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt
Biological Activity
Calcium ionophore; more specific than A23187.

Free Acid also available.

Technical Data
  • M.Wt:
    747.08
  • Formula:
    C41H70O9.Ca
  • Solubility:
    Soluble to 100 mM in ethanol and to 25 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    56092-82-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Characterization of ionomycin as a calcium ionophore.
    Liu and Hermann
    J.Biol.Chem., 1978;253:5892
  2. Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.
    Kaufmann et al.
    J.Biol.Chem., 1980;255:2735
  3. Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils.
    Elzi et al.
    Am.J.Physiol.Cell Physiol., 2001;281:C350
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ionomycin calcium salt include:

8 Citations: Showing 1 - 8
Filter your results:

  1. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    PLoS One 2015;6
  2. Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype.
    Authors: Plog Et al.
    PLoS One 2015;10:e0140050
  3. Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.
    Authors: Jonas Et al.
    J Pharmacol Exp Ther 2015;10:e0139107
  4. TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
    Authors: Shambharkar Et al.
    MBio 2015;10:e0127480
  5. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
    Authors: Soltoff and Lannon
    PLoS One 2013;8:e72881
  6. Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B.
    Authors: Barcomb Et al.
    Mol Pharmacol 2013;84:834
  7. Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1.
    Authors: Selway Et al.
    PLoS One 2012;7:e33004
  8. Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cells.
    Authors: Ohya Et al.
    J Biol Chem 2011;286:16940

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