Ionomycin calcium salt

Catalog # Availability Size / Price Qty
Ionomycin calcium salt | CAS No. 56092-82-1 | Calcium Signaling Agents
1 Image
Description: Calcium ionophore

Chemical Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt

Purity: ≥98%

Product Details
Citations (17)
Reviews (2)

Biological Activity

Calcium ionophore; more specific than A23187.

Free Acid also available.

Technical Data

Soluble to 100 mM in ethanol and to 25 mM in DMSO with gentle warming
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Ionomycin calcium salt

The citations listed below are publications that use Tocris products. Selected citations for Ionomycin calcium salt include:

17 Citations: Showing 1 - 10

  1. Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury.
    Authors: Su Et al.
    Glia  2019;67:78
  2. Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
    Authors: Nieuwenhuijze Et al.
    Front Immunol  2018;9:2234
  3. Probing Internalization Effects and Biocompatibility of Ultrasmall Zirconium Metal-Organic Frameworks UiO-66 NP in U251 Glioblastoma Cancer Cells.
    Authors: Arcuri Et al.
    Nanomaterials (Basel)  2018;8
  4. Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair.
    Authors: Mikolajewicz Et al.
    Elife  2018;7
  5. Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium.
    Authors: Mihara Et al.
    PLoS One  2018;13:e0206276
  6. Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells.
    Authors: Son Et al.
    J Dent Res  2015;94:473
  7. Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane.
    Authors: Azab Et al.
    PLoS One  2015;6
  8. Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype.
    Authors: Plog Et al.
    PLoS One  2015;10:e0140050
  9. Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.
    Authors: Jonas Et al.
    J Pharmacol Exp Ther  2015;10:e0139107
  10. TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
    Authors: Shambharkar Et al.
    MBio  2015;10:e0127480


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Ionomycin Ca depletes intracellular Ca stores.
By Anonymous on 01/11/2020
Application: Species: Human

HEK293 cells were loaded with intracellular Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 40 min in dark at room temperature, washed and kept in normal tyrode for 20 min. Fura2-loaded cells were excited at 340 and 380 nm and fluorescence at 510 nm was expressed as F340/F380 ratio, as an index of cytosolic Ca2+. Ca2+ stores were depleted with 1 µM ionomycin Ca in nominally Ca2+ free-tyrode solution, resulting in cytosolic Ca2+ peak.

Calcium increase
By Anonymous on 10/02/2018
Application: Species: Mouse

Elicits calcium increase, used as a positive control at the end of calcium imaging experiments.

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