Ionomycin free acid

Catalog # Availability Size / Price Qty
2092/1
Ionomycin free acid | CAS No. 56092-81-0 | Calcium Signaling Agents
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Description: Calcium ionophore

Chemical Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid

Product Details
Citations (1)
Reviews (2)

Biological Activity

Calcium ionophore; more specific than A23187.

Calcium Salt also available.

Technical Data

M.Wt:
709.01
Formula:
C41H72O9
Solubility:
Soluble to 10 mM in ethanol and to 10 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
56092-81-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Ionomycin free acid

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Ionomycin releases Ca2+ from intracellular stores.
By Anonymous on 01/02/2020
Application: Species: Human

HEK293 cells were loaded with 1 µM intracellular Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 30 min in dark, washed, and left to equilibrate for 15 min. Fura2-loaded cells were excited alternately at 340 and 380 nm and the fluorescence at 510 nm was expressed as 340/380 ratio to indicate intracellular Ca2+ levels. Application of 1 µM ionomycin in Ca2+-free tyrode solution released Ca2+ from intracellular stores, manifested as a transient peak in fluorescence ratio.


Ionomycin increases flow of extracellular Ca2+ Into cells leading to increased T-cell activation by IFNg
By Li Zhu on 01/23/2019
Application: Species: Human

Ionomycin was used as a calcium ionophore to bring large amounts of extracellular Ca2+ into activated CD8+ T-cells. With high intracellular Ca2+, this led to increased activation of CD8+ T-cells as measured by IFNg production via intracellular flow cytometry.


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