Ionomycin free acid
Chemical Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of ionomycin as a calcium ionophore.
Liu and Hermann
Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.
Kaufmann et al.
Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils.
Elzi et al.
Am.J.Physiol.Cell Physiol., 2001;281:C350
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Ionomycin was used as a calcium ionophore to bring large amounts of extracellular Ca2+ into activated CD8+ T-cells. With high intracellular Ca2+, this led to increased activation of CD8+ T-cells as measured by IFNg production via intracellular flow cytometry.