Catalog Number: 0683
Chemical Name: Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
Biological Activity
P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS.

2'4'-isomer also available.

Technical Data
  • M.Wt:
    599.3
  • Formula:
    C14H10N3Na4O12PS2
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    207572-67-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia.
    Connolly
    Br.J.Pharmacol., 1995;114:727
  2. Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens.
    Khakh et al.
    Eur.J.Pharmacol., 1994;263:301
  3. The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate.
    Trezise et al.
    Br.J.Pharmacol., 1994;112:282
Citations:

The citations listed below are publications that use Tocris products. Selected citations for iso-PPADS tetrasodium salt include:

1 Citations: Showing 1 - 1

  1. Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells.
    Authors: Schneider Et al.
    Am J Physiol Renal Physiol 2015;14:201

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