PPADS tetrasodium salt

Catalog # Availability Size / Price Qty
PPADS tetrasodium salt | CAS No. 192575-19-2 | P2X Receptor Antagonists
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Description: Non-selective P2 antagonist

Chemical Name: Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt

Product Details
Citations (26)
Supplemental Products

Biological Activity

PPADS tetrasodium salt is a non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors. PPADS tetrasodium salt delays onset of calcium responses to mild hypoosmotic stress in cortical slices. PPADS tetrasodium salt blocks P2X7 and reduces clinical and histological graft-versus-host disease development in a humanised mouse model.

2'5'-isomer also available.

Technical Data

Soluble to 100 mM in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PPADS tetrasodium salt

The citations listed below are publications that use Tocris products. Selected citations for PPADS tetrasodium salt include:

26 Citations: Showing 1 - 10

  1. Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo.
    Authors: Takata and Hirase
    PLoS One  ;3:e2525
  2. Autocrine regulation of wound healing by ATP release and P2Y 2 receptor activation
    Authors: McEwan Et al.
    Life Sci  2021;283:119850
  3. P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model.
    Authors: Cuthbertson Et al.
    Clin.Sci.  2021;135:495
  4. Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance.
    Authors: Miguel Cruz & Beall
    Front Physiol  2020;11:567378
  5. Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor.
    Authors: Coddou Et al.
    Neurosci Lett  2019;690:219
  6. Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor.
    Authors: Conley
    PLoS One  2017;12(11):e0187481
  7. Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells.
    Authors: Zhang Et al.
    Sci Rep  2016;6:28938
  8. Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury
    Authors: Yamashita Et al.
    PLoS One  2016;11:e0165189
  9. Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse.
    Authors: Pozner Et al.
    Front Mol Neurosci  2015;8:12
  10. Diadenosine tetraphosphate contributes to CB-induced tear secretion.
    Authors: Fonseca Et al.
    Purinergic Signal  2015;11:87
  11. Pharmacological and molecular characterization of functional P2 receptors in rat embryonic cardiomyocytes.
    Authors: Cheung Et al.
    J Mol Neurosci  2015;11:127
  12. NTPDase1 activity attenuates microglial phagocytosis.
    Authors: Bulavina Et al.
    Purinergic Signal  2013;9:199
  13. Modulation of ATP-induced LTP by cannabinoid receptors in rat hippocampus.
    Authors: Ievglevskyi Et al.
    Purinergic Signal  2012;8:705
  14. Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue.
    Authors: Rodríguez-Zayas Et al.
    Neuropsychopharmacology  2012;46:167
  15. Diacylglycerol signaling underlies astrocytic ATP release.
    Authors: Mungenast
    Neural Plast  2011;2011:537659
  16. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses.
    Authors: Kouzaki Et al.
    J Immunol  2011;186:4375
  17. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
    Authors: Thrane Et al.
    Proc Natl Acad Sci U S A  2011;108:846
  18. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
    Authors: Gómez-Gonzalo Et al.
    PLoS Biol  2010;8:e1000352
  19. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
    Authors: Kennedy Et al.
    J Neurosci  2007;27:845
  20. Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties.
    Authors: Zhong Et al.
    Br J Pharmacol  2001;132:221
  21. Rat chromaffin cells lack P2X receptors while those of the guinea-pig express a P2X receptor with novel pharmacology.
    Authors: Liu Et al.
    Br J Pharmacol  1999;128:61
  22. Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A2.
    Authors: Gao Et al.
    Br J Pharmacol  1999;127:1597
  23. Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons.
    Authors: Zhong Et al.
    Br J Pharmacol  1998;125:771
  24. P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint.
    Authors: Dowd Et al.
    Br J Pharmacol  1998;125:341
  25. Adenosine A1 receptor-mediated excitation of nociceptive afferents innervating the normal and arthritic rat knee joint.
    Authors: Dowd Et al.
    Br J Pharmacol  1998;125:1267
  26. Modulation of extracellular GABA levels in the retina by activation of glial P2X-purinoceptors.
    Authors: Neal Et al.
    Br J Pharmacol  1998;124:317


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