Catalog Number: 0625
Chemical Name: Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt
Biological Activity
A non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors. Delays onset of calcium responses to mild hypoosmotic stress in cortical slices. iso-PPADS (Cat. No. 0683) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
    Thrane et al.
    Proc.Natl.Acad.Sci.U S A, 2011;108:846
  2. Receptors for purines and pyrimidines.
    Ralevic and Burnstock
    Pharmacol.Rev., 1998;50:413
  3. Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens.
    McLaren et al.
    Br.J.Pharmacol., 1994;111:913
  4. Selective antagonism by PPADS at P2x-purinoceptors in rabbit isolated blood vessels.
    Ziganshin et al.
    Br.J.Pharmacol., 1994;111:923
  5. PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses.
    Lambrecht et al.
    Eur.J.Pharmacol., 1992;217:217

The citations listed below are publications that use Tocris products. Selected citations for PPADS tetrasodium salt include:

Showing Results 1 - 10 of 16

  1. Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse.
    Authors: Pozner Et al.
    Front Mol Neurosci
  2. Diadenosine tetraphosphate contributes to carbachol-induced tear secretion.
    Authors: Fonseca Et al.
    Purinergic Signal
  3. Pharmacological and molecular characterization of functional P2 receptors in rat embryonic cardiomyocytes.
    Authors: Cheung Et al.
    J Mol Neurosci
  4. NTPDase1 activity attenuates microglial phagocytosis.
    Authors: Bulavina Et al.
    Purinergic Signal
  5. Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue.
    Authors: Rodríguez-Zayas Et al.
  6. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses.
    Authors: Kouzaki Et al.
    J Immunol
  7. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
    Authors: Thrane Et al.
    Proc Natl Acad Sci U S A
  8. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
    Authors: Gómez-Gonzalo Et al.
    PLoS Biol
  9. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
    Authors: Kennedy Et al.
    J Neurosci
  10. Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties.
    Authors: Zhong Et al.
    Br J Pharmacol
  11. Rat chromaffin cells lack P2X receptors while those of the guinea-pig express a P2X receptor with novel pharmacology.
    Authors: Liu Et al.
    Br J Pharmacol
  12. Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A2.
    Authors: Gao Et al.
    Br J Pharmacol
  13. Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons.
    Authors: Zhong Et al.
    Br J Pharmacol
  14. P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint.
    Authors: Dowd Et al.
    Br J Pharmacol
  15. Modulation of extracellular GABA levels in the retina by activation of glial P2X-purinoceptors.
    Authors: Neal Et al.
    Br J Pharmacol
  16. Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo.
    Authors: Takata and Hirase
    PLoS One
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