PPADS tetrasodium salt

  ( 20 citations )    
Product Datasheet
Catalog Number:0625
Chemical Name:Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt
Product Details
Citations (20)
Supplemental Products
Reviews
Biological Activity
A non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors. Delays onset of calcium responses to mild hypoosmotic stress in cortical slices.

2'5'-isomer also available.

Technical Data
  • M.Wt:
    599.3
  • Formula:
    C14H10N3Na4O12PS2
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    192575-19-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PPADS tetrasodium salt include:

20 Citations: Showing 1 - 10
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  1. Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo.
    Authors: Takata and Hirase
    PLoS One  ;3:e2525
  2. Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor.
    Authors: Conley
    PLoS One  2017;12(11):e0187481
  3. Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury
    Authors: Yamashita Et al.
    PLoS One  2016;11:e0165189
  4. Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse.
    Authors: Pozner Et al.
    Front Mol Neurosci  2015;8:12
  5. Diadenosine tetraphosphate contributes to carbachol-induced tear secretion.
    Authors: Fonseca Et al.
    Purinergic Signal  2015;11:87
  6. Pharmacological and molecular characterization of functional P2 receptors in rat embryonic cardiomyocytes.
    Authors: Cheung Et al.
    J Mol Neurosci  2015;11:127
  7. NTPDase1 activity attenuates microglial phagocytosis.
    Authors: Bulavina Et al.
    Purinergic Signal  2013;9:199
  8. Modulation of ATP-induced LTP by cannabinoid receptors in rat hippocampus.
    Authors: Ievglevskyi Et al.
    Purinergic Signal  2012;8:705
  9. Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue.
    Authors: Rodríguez-Zayas Et al.
    Neuropsychopharmacology  2012;46:167
  10. Diacylglycerol signaling underlies astrocytic ATP release.
    Authors: Mungenast
    Neural Plast  2011;2011:537659
  11. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses.
    Authors: Kouzaki Et al.
    J Immunol  2011;186:4375
  12. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
    Authors: Thrane Et al.
    Proc Natl Acad Sci U S A  2011;108:846
  13. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
    Authors: Gómez-Gonzalo Et al.
    PLoS Biol  2010;8:e1000352
  14. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
    Authors: Kennedy Et al.
    J Neurosci  2007;27:845
  15. Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties.
    Authors: Zhong Et al.
    Br J Pharmacol  2001;132:221
  16. Rat chromaffin cells lack P2X receptors while those of the guinea-pig express a P2X receptor with novel pharmacology.
    Authors: Liu Et al.
    Br J Pharmacol  1999;128:61
  17. Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A2.
    Authors: Gao Et al.
    Br J Pharmacol  1999;127:1597
  18. Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons.
    Authors: Zhong Et al.
    Br J Pharmacol  1998;125:771
  19. P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint.
    Authors: Dowd Et al.
    Br J Pharmacol  1998;125:341
  20. Modulation of extracellular GABA levels in the retina by activation of glial P2X-purinoceptors.
    Authors: Neal Et al.
    Br J Pharmacol  1998;124:317
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