A non-selective P2 purinergic antagonist. Blocks recombinant P2X1
= 1 - 2.6 μ
M), native P2Y2
~ 0.9 mM), and recombinant P2Y4
~ 15 mM) receptors. Delays onset of calcium responses to mild hypoosmotic stress in cortical slices. iso-PPADS
(Cat. No. 0683) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
Thrane et al.
Proc.Natl.Acad.Sci.U S A, 2011;108:846
Receptors for purines and pyrimidines.
Ralevic and Burnstock
Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens.
McLaren et al.
Selective antagonism by PPADS at P2x-purinoceptors in rabbit isolated blood vessels.
Ziganshin et al.
PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses.
Lambrecht et al.
The citations listed below are publications that use Tocris products. Selected citations for PPADS tetrasodium salt include:
Showing Results 1 - 10 of 16