PPADS tetrasodium salt

Tocris Bioscience | Catalog # 0625

Non-selective P2 antagonist
Tocris Bioscience

Key Product Details

Description

Non-selective P2 antagonist
View all P2X Receptor Antagonists »

Product Description

PPADS tetrasodium salt is a non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors. PPADS tetrasodium salt delays onset of calcium responses to mild hypoosmotic stress in cortical slices. PPADS tetrasodium salt blocks P2X7 and reduces clinical and histological graft-versus-host disease development in a humanised mouse model.

2'5'-isomer also available.

Product Specifications for PPADS tetrasodium salt

Molecular Weight

599.30

Formula

C14H10N3Na4O12PS2

Storage

Desiccate at -20°C

Chemical Name

Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt

CAS Number

192575-19-2

PubChem ID

101086948

InChI Key

KURWUCJJNVPCHT-UHFFFAOYSA-J

SMILES

[Na+].[Na+].[Na+].[Na+].CC1=C(O)C(C=O)=C(COP([O-])([O-])=O)C(\N=N\C2=C(C=C(C=C2)S([O-])(=O)=O)S([O-])(=O)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for PPADS tetrasodium salt

The following data is based on the product molecular weight 599.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.67 mL 8.34 mL 16.69 mL
5 mM 0.33 mL 1.67 mL 3.34 mL
10 mM 0.17 mL 0.83 mL 1.67 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 42 publications citing the usage of this product.

Product Documents for PPADS tetrasodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PPADS tetrasodium salt

For research use only

Citations for PPADS tetrasodium salt

Customer Reviews for PPADS tetrasodium salt (2)

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  • Blocker of P2X channels
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Cortical neurons
    Verified Customer | Posted 08/03/2021
    Study calcium oscillations using Fura2-AM in neuronal cultures at 10 micromolar concentration.
    PPADS tetrasodium salt 0625
  • P2X antagonist
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 10/02/2018
    used to abrogate P2X responses, worked as expected.

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