A non-selective P2 purinergic antagonist. Blocks recombinant P2X
= 1 - 2.6
M), native P2Y
~ 0.9 mM), and recombinant P2Y
~ 15 mM) receptors. Delays onset of calcium responses to mild hypoosmotic stress in cortical slices.
2'5'-isomer also available.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
Thrane et al.
Proc.Natl.Acad.Sci.U S A, 2011;108:846
Receptors for purines and pyrimidines.
Ralevic and Burnstock
Investigation of the actions of PPADS, a novel P 2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens.
McLaren et al.
Selective antagonism by PPADS at P 2x-purinoceptors in rabbit isolated blood vessels.
Ziganshin et al.
PPADS, a novel functionally selective antagonist of P 2 purinoceptor-mediated responses.
Lambrecht et al.
The citations listed below are publications that use Tocris products. Selected citations for PPADS tetrasodium salt include:
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