Catalog Number: 2595
Chemical Name: 1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide
Biological Activity
Potent chemokine receptor 1 (CCR1) antagonist (IC50 values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC50 values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice. Isomer of UCB 35625 (Cat. No. 2757).
Technical Data
  • M.Wt:
    655.44
  • Formula:
    C30H37Cl2IN2O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    353791-85-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Design, synthesis, and discovery of a novel CCR1 antagonist.
    Naya et al.
    J.Med.Chem., 2001;44:1429
  2. Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo.
    Amat et al.
    Br.J.Pharmacol., 2006;149:666
Citations:

The citations listed below are publications that use Tocris products. Selected citations for J 113863 include:

3 Citations: Showing 1 - 3
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  1. The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours.
    Authors: Kamata Et al.
    Biomaterials 2015;7:1119
  2. PGC-1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle.
    Authors: Rowe Et al.
    Circ Res 2014;115:504
  3. Effect of a CCR1 receptor antagonist on systemic trafficking of MSCs and polyethylene particle-associated bone loss.
    Authors: Gibon Et al.
    ScientificWorldJournal 2012;33:3632

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