J 113863

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2595/1
2595/10
2595/50
Cat.No. 2595 - J 113863 | C30H37Cl2IN2O2 | CAS No. 353791-85-2
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Description: Potent CCR1 chemokine receptor antagonist

Chemical Name: 1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews (1)

Biological Activity

Potent chemokine receptor 1 (CCR1) antagonist (IC50 values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC50 values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice.

Isomer also available.

Technical Data

M.Wt:
655.44
Formula:
C30H37Cl2IN2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
353791-85-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

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Citations for J 113863

The citations listed below are publications that use Tocris products. Selected citations for J 113863 include:

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Effective in blocking mouse CCL6 chemotaxis in vitro
By Anonymous on 12/12/2017
Species: Mouse

J113863 was used in a chemotaxis assay using a subset of C57Bl/6 splenic cells. Cells were pretreated with J113863 for 2 hours before being added to the top portion of a transwell assay. CCL6 or media was used and the chemoattractant and cells were given 2 hours to migrate.


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