Potent chemokine receptor 1 (CCR1) antagonist (IC50
values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC50
values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice. Isomer of UCB 35625
(Cat. No. 2757).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Design, synthesis, and discovery of a novel CCR1 antagonist.
Naya et al.
Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo.
Amat et al.
The citations listed below are publications that use Tocris products. Selected citations for J 113863 include:
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