Sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P2
(EDG-5). Inhibits S1P binding to human S1P2
receptors with an IC50
value of 17.6 nM. At concentrations up to 10 μ
M, displays 4.2% inhibition of S1P3
and does not antagonize S1P1
. Enhances S1P-induced angiogenesis in vivo
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Spingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.
Ohmori et al.
Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands.
Parrill et al.
Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor.
Inoki et al.
The citations listed below are publications that use Tocris products. Selected citations for JTE 013 include:
Showing Results 1 - 10 of 17