JTE 013

  ( 19 citations )    
Product Datasheet
Catalog Number:2392
Chemical Name:1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide
Product Details
Citations (19)
Supplemental Products
Reviews
Biological Activity
Sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P2 (EDG-5). Inhibits S1P binding to human S1P2 receptors with an IC50 value of 17.6 nM. At concentrations up to 10 μM, displays 4.2% inhibition of S1P3 and does not antagonize S1P1. Enhances S1P-induced angiogenesis in vivo.
Technical Data
  • M.Wt:
    408.29
  • Formula:
    C17H19N7OCl2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    547756-93-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for JTE 013 include:

19 Citations: Showing 1 - 10
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  1. Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics.
    Authors: Kellner Et al.
    Hippocampus  2016;6:816
  2. Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2.
    Authors: Chumanevich Et al.
    Mediators Inflamm  2016;2016:1503206
  3. Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells
    Authors: Wirrig Et al.
    Biochemical Pharmacology  2016;115:43
  4. Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy?
    Authors: Durham Et al.
    Arthritis Rheum  2015;56:3441
  5. Defective apical extrusion signaling contributes to aggressive tumor hallmarks.
    Authors: Gu Et al.
    Elife  2015;4:e04069
  6. Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells.
    Authors: Fernández-Pisonero Et al.
    Am J Physiol Heart Circ Physiol  2014;9:e109081
  7. Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α).
    Authors: Shen Et al.
    Cell Stress Chaperones  2014;19:541
  8. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.
    Authors: Beckham Et al.
    PLoS One  2013;8:e76593
  9. Sphingosine 1-phosphate counteracts the effects of interleukin-1β in human chondrocytes.
    Authors: Stradner Et al.
    J Urol  2013;65:2113
  10. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
    Authors: Beckham Et al.
    Oncogenesis  2013;2:e49
  11. Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways.
    Authors: Quint Et al.
    PLoS One  2013;288:5398
  12. The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement.
    Authors: Green Et al.
    Nat Immunol  2011;12:672
  13. Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis.
    Authors: Frias Et al.
    Mol Cancer Res  2010;85:118
  14. S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate.
    Authors: Szczepaniak Et al.
    Am J Physiol Lung Cell Mol Physiol  2010;299:L137
  15. Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules.
    Authors: Zhang Et al.
    Cardiovasc Res  2010;299:H1494
  16. Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.
    Authors: Long Et al.
    J Biol Chem  2010;285:35957
  17. S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor.
    Authors: Li Et al.
    J Biol Chem  2009;181:1347
  18. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2.
    Authors: Li Et al.
    J Clin Endocrinol Metab  2008;6:1649
  19. Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells.
    Authors: Miller Et al.
    Mol Cell Biol  2008;28:4142
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