Selective inhibitor of mammalian target of rapamycin (mTOR) (IC50
~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1
cell cycle arrest in vitro
Soluble to 10 mM in DMSO
Store at RT
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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).
Garcia-Martinez et al.
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