Chemical Name: rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Biological ActivityKU 0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).
Garcia-Martinez et al.
Citations for KU 0063794
The citations listed below are publications that use Tocris products. Selected citations for KU 0063794 include:
10 Citations: Showing 1 - 10
The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development.
Authors: Xing Et al.
Front Cell Dev Biol 2018;6:134
The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.
Authors: Bodur Et al.
EMBO J 2018;37:19
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.
Authors: Gandin Et al.
Nat Commun 2016;7:11127
The cytotoxic T cell proteome and its shaping by the kinase mTOR.
Authors: Hukelmann Et al.
J Biol Chem 2016;17:104
mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.
Authors: Munson Et al.
Nat Immunol 2015;34:2272
A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
Authors: López-Cotarelo Et al.
Proc Natl Acad Sci U S A 2015;290:827
SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
Authors: Wang Et al.
PLoS One 2014;8:e83941
Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells.
Authors: Fei Et al.
PLoS One 2013;8:e69104
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
EMBO J 2013;64:4361
Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.
Authors: Sengupta Et al.
Free Radic Biol Med 2013;110:18826
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