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KU 0063794

Catalog #: 3725
10 Citations Datasheet / COA / SDS
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3725/10
KU 0063794 | CAS No. 938440-64-3 | mTOR Inhibitors
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Description: Selective mTOR inhibitor

Chemical Name: rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol

Purity: ≥97%

Product Details
Citations (10)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

KU 0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro.

Technical Data

M.Wt:
465.54
Formula:
C25H31N5O4
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥97%
Storage:
Store at RT
CAS No:
938440-64-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).
    Garcia-Martinez et al.
    Biochem.J., 2009;421:29

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Citations for KU 0063794

The citations listed below are publications that use Tocris products. Selected citations for KU 0063794 include:

10 Citations: Showing 1 - 10

  1. The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development.
    Authors: Xing Et al.
    Front Cell Dev Biol  2018;6:134
  2. The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.
    Authors: Bodur Et al.
    EMBO J  2018;37:19
  3. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.
    Authors: Gandin Et al.
    Nat Commun  2016;7:11127
  4. The cytotoxic T cell proteome and its shaping by the kinase mTOR.
    Authors: Hukelmann Et al.
    J Biol Chem  2016;17:104
  5. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.
    Authors: Munson Et al.
    Nat Immunol  2015;34:2272
  6. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
    Authors: López-Cotarelo Et al.
    Proc Natl Acad Sci U S A  2015;290:827
  7. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Authors: Wang Et al.
    PLoS One  2014;8:e83941
  8. Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells.
    Authors: Fei Et al.
    PLoS One  2013;8:e69104
  9. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
    Authors: Montané and Menand
    EMBO J  2013;64:4361
  10. Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.
    Authors: Sengupta Et al.
    Free Radic Biol Med  2013;110:18826

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