Catalog Number: 3725
Chemical Name: rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Biological Activity
Selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro.
Technical Data
  • M.Wt:
    465.54
  • Formula:
    C25H31N5O4
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at RT
  • CAS No:
    938440-64-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes only under agreement from KUDOS
Background References
  1. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).
    Garcia-Martinez et al.
    Biochem.J., 2009;421:29
Citations:

The citations listed below are publications that use Tocris products. Selected citations for KU 0063794 include:

7 Citations: Showing 1 - 7
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  1. The cytotoxic T cell proteome and its shaping by the kinase mTOR.
    Authors: Hukelmann Et al.
    J Biol Chem 2016;17:104
  2. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.
    Authors: Munson Et al.
    Nat Immunol 2015;34:2272
  3. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
    Authors: López-Cotarelo Et al.
    Proc Natl Acad Sci U S A 2015;290:827
  4. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Authors: Wang Et al.
    PLoS One 2014;8:e83941
  5. Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells.
    Authors: Fei Et al.
    PLoS One 2013;8:e69104
  6. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
    Authors: Montané and Menand
    EMBO J 2013;64:4361
  7. Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.
    Authors: Sengupta Et al.
    Free Radic Biol Med 2013;110:18826

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