KU 0063794

Catalog # Availability Size / Price Qty
KU 0063794 | CAS No. 938440-64-3 | mTOR Inhibitors
1 Image
Description: Selective mTOR inhibitor

Chemical Name: rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol

Purity: ≥97%

Product Details
Citations (10)

Biological Activity

KU 0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro.

Technical Data

Soluble to 10 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).
    Garcia-Martinez et al.
    Biochem.J., 2009;421:29

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for KU 0063794

The citations listed below are publications that use Tocris products. Selected citations for KU 0063794 include:

10 Citations: Showing 1 - 10

  1. The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development.
    Authors: Xing Et al.
    Front Cell Dev Biol  2018;6:134
  2. The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.
    Authors: Bodur Et al.
    EMBO J  2018;37:19
  3. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.
    Authors: Gandin Et al.
    Nat Commun  2016;7:11127
  4. The cytotoxic T cell proteome and its shaping by the kinase mTOR.
    Authors: Hukelmann Et al.
    J Biol Chem  2016;17:104
  5. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.
    Authors: Munson Et al.
    Nat Immunol  2015;34:2272
  6. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
    Authors: López-Cotarelo Et al.
    Proc Natl Acad Sci U S A  2015;290:827
  7. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Authors: Wang Et al.
    PLoS One  2014;8:e83941
  8. Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells.
    Authors: Fei Et al.
    PLoS One  2013;8:e69104
  9. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
    Authors: Montané and Menand
    EMBO J  2013;64:4361
  10. Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.
    Authors: Sengupta Et al.
    Free Radic Biol Med  2013;110:18826


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for KU 0063794

There are currently no reviews for this product. Be the first to review KU 0063794 and earn rewards!

Have you used KU 0063794?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.