L-Glutamic acid

Catalog # Availability Size / Price Qty
L-Glutamic acid | CAS No. 56-86-0 | Non-selective mGluR Agonists
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Description: Endogenous, non-selective glutamate receptor agonist

Chemical Name: (S)-1-Aminopropane-1,3-dicarboxylic acid

Product Details
Citations (9)
Supplemental Products

Biological Activity

L-Glutamic acid is a the predominant excitatory transmitter in the mammalian central nervous system. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.

MNI-caged-L-glutamate (Cat. No. 1490) also available.

Technical Data

Soluble to 100 mM in 1eq. NaOH
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system.
    Monaghan et al.
    Annu.Rev.Pharmacol.Toxicol., 1989;29:365
  2. Excitatory amino acid transmitters.
    Watkins and Evans
    Annu.Rev.Pharmacol.Toxicol., 1981;21:165
  3. Ferroptosis: Death by lipid peroxidation.
    Yang and Stockwell et al.
    Trends Cell Biol., 2016;26:165

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for L-Glutamic acid

The citations listed below are publications that use Tocris products. Selected citations for L-Glutamic acid include:

9 Citations: Showing 1 - 9

  1. Multi-target action of �-alanine protects cerebellar tissue from ischemic damage.
    Authors: Kopach Et al.
    Cell Death Dis  2022;13:747
  2. Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model.
    Authors: Falcucci Et al.
    ACS Chem Neurosci  2019;10:3437
  3. Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
    Authors: Schitine Et al.
    J Neurosci  2015;82:42
  4. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
    Authors: Owaisat Et al.
    Neurosci Lett  2012;525:12
  5. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
    Authors: Tallarida Et al.
    Amino Acids  2012;42:2521
  6. Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A�mGlu2) receptor heteromerization and its psychoactive behavioral function.
    Authors: Moreno Et al.
    J Biol Chem  2012;287:44301
  7. Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring.
    Authors: Moreno Et al.
    J Neurosci  2011;31:1863
  8. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
    Authors: Galici Et al.
    J Pharmacol Exp Ther  2006;318:173
  9. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
    Authors: Calò Et al.
    J Neurosci  2005;25:2245


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