Key Product Details

Species Reactivity

Human

Applications

Knockout Validated, Western Blot

Label

Biotin

Antibody Source

Monoclonal Mouse IgG2A Clone # 873502
View all LKB1/STK11 Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human LKB1/STK11
Met1-Gln433
Accession # Q15831

Specificity

Detects human LKB1/STK11 in direct ELISAs and Western blots.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for LKB1/STK11 Antibody (873502) [Biotin]

Application
Recommended Usage

Knockout Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: LKB1/STK11

Peutz-Jeghers syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. LKB1 (also designated STK11 and PJS) has been identified as the gene mutated in PJS. LKB1 is a 433 amino acid Serine/Threonine kinase with strong homology to the Xenopus cytoplasmic protein kinase XEEK1 and weaker similarity to many other protein kinases. LKB1 is ubiquitously expressed and many frameshift, deletion and splicing mutations have been identified in PJS patients. Despite the increased risk of cancer for PJS patients, LKB1 does not appear to play a major role in colorectal, testicular or breast cancers.

Long Name

Serine/threonine Protein Kinase LKB1

Alternate Names

PJS, STK11

Gene Symbol

STK11

Additional LKB1/STK11 Products

Product Documents for LKB1/STK11 Antibody (873502) [Biotin]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for LKB1/STK11 Antibody (873502) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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Associated Pathways

mTOR Signaling Pathway mTOR Signaling Pathway Thumbnail