MK 0677

Catalog # Availability Size / Price Qty
5272/10
5272/50
MK 0677 | CAS No. 159752-10-0 | Ghrelin Receptor Agonists
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Description: High affinity ghrelin receptor agonist
Alternative Names: Ibutamoren mesylate, L-163,191

Chemical Name: 2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

MK 0677 is a high affinity ghrelin receptor agonist (pKi = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol-induced lipolysis in rat adipocytes in vitro. Orally bioavailable.

Technical Data

M.Wt:
624.77
Formula:
C27H36N4O5S.CH3SO3H
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
159752-10-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for MK 0677

The citations listed below are publications that use Tocris products. Selected citations for MK 0677 include:

1 Citation: Showing 1 - 1

  1. A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity In vivo
    Authors: Pastor-Cavada Et al.
    Scientific Reports  2016;6:36456

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