Mouse CCR2 Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CCR2

CCR2, also known as CD192, is a 38 kDa 7TM chemokine receptor that preferentially binds CCL2, CCL7, and CCL13. CCR2 is expressed by multiple hematopoietic cells, endothelial cells, fibroblasts, neurons, and smooth muscle cells. It functions as an HIV fusion co-factor and facilitates T cell recruitment during inflammation. Two alternate splice forms (CCR2A and CCR2B) differ only by the addition of 14 amino acids to the intracellular carboxyl terminal. Mouse CCR2 shares 67% and 95% aa sequence identity with human and rat CCR2, respectively.

Product Datasheets

Related Research Areas

• CC Chemokines and Receptors
• Chemokine Receptors
• Chemokines and Receptors in Allergy and Asthma
• Chemokines and Receptors in Angiogenesis
• Cytokine and Growth Factor Receptors on VSMC
• G Protein-Coupled Receptors in Immune Responses
• G Protein-Coupled Receptors in Obesity and Related Metabolic Disorders
• Macrophage Activation Markers
• Microglia Development
• Monocyte Markers
• Myeloid Lineage Markers
• Myeloid-derived Suppressor Cells (MDSC)
• Obesity
• Platelet Cytokine and Growth Factor Receptors
• Receptors in the Jak/STAT Pathway
• Regulatory T Cells (Tregs)
• T Cell Migration/Adhesion
• Uptake of Amyloid beta by Macrophages