Mouse CXCR5 (CAA50673) VersaClone cDNA

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RDC0036
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Mouse CXCR5 (CAA50673) VersaClone cDNA Summary

Key Benefits

CXCR5, also known as Burkitt Lymphoma Receptor 1, is a G protein-coupled receptor (GPCR) member of the CXC subfamily of chemokine receptors. Human CXCR5 is 372 amino acids (aa) in length with a predicted molecular weight of 42 kDa. Mouse and rat CXCR5 share 83% and 81% aa sequence identity with the human protein, respectively. CXCR5 is primarily expressed on B cells and binds CXCL13/BCL/BCA-1. The CXCL13/BCL/BCA-1:CXCR5 axis regulates B cell migration within secondary lymphoid organs such as the spleen and Peyer’s patches. CXCR5 is also expressed on follicular helper T cells and dermal-derived migratory dendritic cells where it is thought to promote the humeral immune response by meditating germinal center reactions and B cell activation. Polymorphisms of CXCR5 are associated with multiple types of non-Hodgkin’s lymphoma, and it is expressed on Burkitt’s lymphoma cells.

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Mouse

Product Datasheets

Background: CXCR5

CXCR5, also known as Burkitt Lymphoma Receptor 1, is a G protein-coupled receptor (GPCR) member of the CXC subfamily of chemokine receptors. Human CXCR5 is 372 amino acids (aa) in length with a predicted molecular weight of 42 kDa. Mouse and rat CXCR5 share 83% and 81% aa sequence identity with the human protein, respectively. CXCR5 is primarily expressed on B cells and binds CXCL13/BCL/BCA-1. The CXCL13/BCL/BCA-1:CXCR5 axis regulates B cell migration within secondary lymphoid organs such as the spleen and Peyer’s patches. CXCR5 is also expressed on follicular helper T cells and dermal-derived migratory dendritic cells where it is thought to promote the humeral immune response by meditating germinal center reactions and B cell activation. Polymorphisms of CXCR5 are associated with multiple types of non-Hodgkin’s lymphoma, and it is expressed on Burkitt’s lymphoma cells.

Entrez Gene IDs
643 (Human); 12145 (Mouse); 29363 (Rat)
Alternate Names
BLR1; BLR1MDR-15; Burkitt lymphoma receptor 1; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif)receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; CD185 antigen; CD185; chemokine (C-X-C motif) receptor 5; C-X-C chemokine receptor type 5; CXCR5; CXC-R5; MDR15CXCR-5; MGC117347; Monocyte-derived receptor 15

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