Mouse CXCR7/RDC-1 Antibody Summary
Met1-Leu47, Ser103-Lys118, Lys184-Glu213, Leu274-Ala296
Accession # P56485
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of CXCR7 in D3 Mouse Cell Line by Flow Cytometry. D3 mouse embryonic stem cell line was stained with Rat Anti-Mouse CXCR7/RDC‑1 Monoclonal Antibody (Catalog # MAB7167, filled histo-gram) or isotype control antibody rat IgM (open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgM Secondary Antibody.
Detection of CXCR7 in HEK293 Human Cell Line Transfected with eGFP and Mouse CXCR7/RDC-1 by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with eGFP and Mouse CXCR7/RDC-1 were stained with Rat Anti-Mouse CXCR7/RDC‑1 Monoclonal Antibody (Catalog # MAB7167) followed by Allophycocyanin-conjugated-Anti-Rat IgM secondary antibody. Quadrant markers were set based on control antibody staining.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
CXCR7 (CXC chemokine receptor 7; also GPRN1, RDC-1 and chemokine orphan receptor 1) is a 60 kDa member of the G-protein coupled receptor 1 family. It is expressed on multiple cell types, including neurons, T cells, NK cells, neutrophils, B cells plus angiogenic endothelial cells. CXCR7 forms both homodimers and heterodimers with CXCR4. It selectively binds I-TAC and SDF1, and appears to involve beta -arrestin2 during signaling. Notably, a CXCR7:CXCR4 heterodimer shows increased responsiveness to SDF1, and I-TAC may actually block some SDF1-mediated migration activity. Mouse CXCR7 is a 7-transmembrane glycoprotein that is 362 amino acids (aa) in length. It contains a 47 aa N-terminal extracellular region plus a 43 aa C-terminal cytoplasmic domain. Over the collective extracellular domains (aa 1-47, 103-118, 184-213 and 274-296), mouse CXCR7 shares 97% and 91% aa identity with rat and human CXCR7, respectively.
Citation for Mouse CXCR7/RDC-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4.
Authors: Chen Q, Zhang M, Li Y, Xu D, Wang Y, Song A, Zhu B, Huang Y, Zheng J
Stem Cells, 2015;33(8):2574-85.
Sample Types: Whole Cells
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