Mouse IGFALS/ALS Alexa Fluor® 700-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: IGFALS/ALS

ALS (Acid labile subunit) is an 84-86 kDa glycoprotein member of the leucine rich repeat superfamily of molecules.  It is secreted by hepatocytes in response to growth hormone stimulation, and forms a 140-150 kDa ternary complex with IGFBP3 (or IGFBP5) and IGF-I.  This complex increases the half-life of IGF-I and retains it in the circulation for use in multiple tissues.  Mature mouse ALS is 580 amino acids (aa) in length (aa 24-603).  It contains twenty-one 20-23 aa LRRs that participate in protein-protein interactions.  There are two potential isoform variants that show N-terminal extensions.  One contains a 66 aa substitution for aa 1-5, while another possesses an 89 aa substitution again for aa 1-5.  Over aa 28-603, mouse ALS shares 79% and 93% aa identity with human and rat ALS, respectively.        

Product Datasheets

Related Research Areas

• Diabetes
• IGF Family
• Metabolic Peptide Hormones and Regulators