IL-15Ra (Interleukin 15 Receptor alpha), also known as CD215, is a transmembrane glycoprotein that plays an important role in NK and CD8+ memory T cell homeostasis and activation. It transmits IL-15 induced signals and additionally interacts with a complex of IL-2Rβ and the common gamma chain (γc) which are also subunits of the IL-2 receptor complex. In transpresentation, IL-15/IL-15Ra complexes are expressed on the surface of one cell and interact with complexes of IL-2Rb/gc on adjacent cells. IL-15/IL-15Ra complexes can transmit reverse signaling that promotes adhesion and activation of the IL-15/IL-15Ra expressing cells. Shed soluble forms of IL-15Ra retain the ability to bind tightly to IL-15 and can inhibit IL-15 bioactivity.
Mouse IL-15R alpha (NP_032384) VersaClone cDNA
R&D Systems | Catalog # RDC1372
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: IL-15R alpha
Long Name
Interleukin 15 Receptor alpha
Alternate Names
CD215, IL-15 R alpha, IL-15Ra, IL15 R alpha, IL15RA
Gene Symbol
IL15RA
UniProt
Additional IL-15R alpha Products
Product Documents for Mouse IL-15R alpha (NP_032384) VersaClone cDNA
Product Specific Notices for Mouse IL-15R alpha (NP_032384) VersaClone cDNA
For research use only
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