IL-17F is a disulfide-linked dimeric cytokine expressed in activated CD4+ T-cells and activated monocytes. It signals through IL-17 RC to stimulate production of IL-6, IL-8, G-CSF, and regulates cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis. IL-17F also inhibits angiogenesis and induces production of IL-2, TGF-beta, and monocyte chemoattractant protein-1 in endothelial cells.
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