Mouse Mer APC-conjugated Antibody

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Detection of Mer in J774A.1 Mouse Cell Line by Flow Cytometry.
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Product Details
Citations (5)
Supplemental Products
Reviews (3)

Mouse Mer APC-conjugated Antibody Summary

Species Reactivity
Detects mouse Mer in direct ELISAs.
Monoclonal Rat IgG2A Clone # 108928
Protein A or G purified from hybridoma culture supernatant
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse Mer
Accession # Q60805
Supplied in a saline solution containing BSA and Sodium Azide.
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)


Recommended Concentration
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of Mer antibody in J774A.1 Mouse Cell Line antibody by Flow Cytometry. View Larger

Detection of Mer in J774A.1 Mouse Cell Line by Flow Cytometry. J774A.1 mouse reticulum cell sarcoma macrophage cell line was stained with Rat Anti-Mouse Mer APC-conjugated Monoclonal Antibody (Catalog # FAB5912A, filled histogram) or isotype control antibody (Catalog # IC006A, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: Mer

Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein Growth-Arrest-Specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions (1-2).

  1. Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
  2. Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.
Long Name
Receptor Tyrosine Protein Kinase Mer
Entrez Gene IDs
10461 (Human); 17289 (Mouse); 102143798 (Cynomolgus Monkey)
Alternate Names
c-Eyk; c-mer proto-oncogene tyrosine kinase; C-mer; EC 2.7.10; EC; MER receptor tyrosine kinase; Mer; MerTK; MGC133349; Receptor tyrosine kinase MerTK; RP38Proto-oncogene c-Mer; STK kinase; tyrosine-protein kinase Mer

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Citations for Mouse Mer APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus
    Authors: DM Patrick, N de la Visi, J Krishnan, W Chen, MJ Ormseth, CM Stein, SS Davies, V Amarnath, LJ Crofford, JM Williams, S Zhao, CD Smart, S Dikalov, A Dikalova, L Xiao, JP Van Beusec, M Ao, AB Fogo, A Kirabo, DG Harrison
    JCI Insight, 2022-07-08;7(13):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis
    Authors: C Miyabe, Y Miyabe, L Moreno, J Lian, RA Rahimi, NN Miura, N Ohno, Y Iwakura, T Kawakami, AD Luster
    J. Clin. Invest., 2019-06-06;130(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Csf1r or Mer inhibition delays liver regeneration via suppression of Kupffer cells
    Authors: JA Santamaria, S Zeng, JB Greer, MJ Beckman, AM Seifert, NA Cohen, JQ Zhang, MH Crawley, BL Green, JK Loo, JH Maltbaek, RP DeMatteo
    PLoS ONE, 2019-05-01;14(5):e0216275.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation
    Proc Natl Acad Sci USA, 2016-05-19;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. The monocyte to macrophage transition in the murine sterile wound.
    Authors: Crane, Meredith, Daley, Jean M, van Houtte, Olivier, Brancato, Samielle, Henry, William, Albina, Jorge E
    PLoS ONE, 2014-01-22;9(1):e86660.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry


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Reviews for Mouse Mer APC-conjugated Antibody

Average Rating: 4.7 (Based on 3 Reviews)

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Mouse Mer APC-conjugated Antibody
By Anonymous on 09/24/2018
Application: In vivo imaging Sample Tested: Liver cells Species: Mouse

In vivo imaging of liver macrophages using intravital laser confocal microscopy. Ccr2/Cx3cr1 transgenic mice were anaesthetised with ketamine and medetomidine, received i.v. injection of fluorophore-conjugated antibodies [anti-F4/80 (BV421) and anti-MerTK (APC)] and then surgical exposure of the liver was performed. Imaging was performed under isofluorane anaesthesia on a Leica SP5 laser scanning confocal microscope using a 20x objective. Videos were recorded at defined regions of interest. Image analysis was performed using Imaris (v 8.0). Representative screen shots of intravital liver imaging videos showing F4/80+ macrophages (blue) expressing MerTK (pink), ccr2 (red) or cx3cr1 (green), located in centrilobular areas of the liver.

Mouse Mer APC-conjugated Antibody
By Anonymous on 09/08/2016
Application: Flow Sample Tested: C1498 Species: Mouse

Mouse Mer APC-conjugated Antibody
By Anonymous on 07/03/2016
Application: Flow Sample Tested: PRIMARY MACROPHAGES Species: Mouse