Mouse Mer PE-conjugated Antibody

(3 citations)
(1 Review)
  
  • Species Reactivity
    Mouse
  • Specificity
    Detects mouse Mer in direct ELISAs.
  • Source
    Monoclonal Rat IgG2A Clone # 108928
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse Mer
    Glu23-Phe498
    Accession # Q60805
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Phycoerythrin
Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of Mer in J774A.1 Mouse Cell Line by Flow Cytometry. J774A.1 mouse reticulum cell sarcoma macrophage cell line was stained with Rat Anti-Mouse Mer PE‑conjugated Monoclonal Antibody (Catalog # FAB5912P, filled histogram) or isotype control antibody (Catalog # IC006P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Mer

Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions (1-2).

  • References:
    1. Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
    2. Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.
  • Long Name:
    Receptor Tyrosine Protein Kinase Mer
  • Entrez Gene IDs:
    10461 (Human); 17289 (Mouse)
  • Alternate Names:
    c-Eyk; c-mer proto-oncogene tyrosine kinase; C-mer; EC 2.7.10; EC 2.7.10.1; MER receptor tyrosine kinase; Mer; MerTK; MGC133349; Receptor tyrosine kinase MerTK; RP38Proto-oncogene c-Mer; STK kinase; tyrosine-protein kinase Mer
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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Species
Applications
Sample Type
  1. Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis.
    Authors: Stijlemans, Benoit, Cnops, Jennifer, Naniima, Peter, Vaast, Axel, Bockstal, Viki, De Baetselier, Patrick, Magez, Stefan
    PLoS Negl Trop Dis, 2015;9(3):e0003561.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Flow
  2. NK-, NKT- and CD8-Derived IFNgamma Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia.
    Authors: Cnops J, De Trez C, Stijlemans B, Keirsse J, Kauffmann F, Barkhuizen M, Keeton R, Boon L, Brombacher F, Magez S
    PLoS Pathog, 2015;11(6):e1004964.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Flow
  3. GAS6 receptor status is associated with dormancy and bone metastatic tumor formation.
    Authors: Taichman, Russell, Patel, Lalit R, Bedenis, Rachel, Wang, Jingchen, Weidner, Savannah, Schumann, Taibrian, Yumoto, Kenji, Berry, Janice E, Shiozawa, Yusuke, Pienta, Kenneth
    PLoS ONE, 2013;8(4):e61873.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Flow
Isotype Controls
Description Application Cat# Citations Images  

Rat IgG2A PE-conjugated Antibody

Ctrl IC006P 16  
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Staining Reagents
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Flow Cytometry Staining Buffer (1X)

Flow FC001 6
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 4
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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Average Rating: 5 (Based on 1 review)

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We have 1 review tested in 1 species: Human.
We have 1 review tested in 1 application: Flow Cytometry.

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Flow Cytometry Mouse Mer PE-conjugated Antibody FAB5912P
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 Flow Human Anonymous 09/08/2016
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Flow Cytometry Mouse Mer PE-conjugated Antibody FAB5912P
Flow Cytometry: Mouse Mer PE-conjugated Antibody [FAB5912P]

Summary

ApplicationFlow Cytometry
Sample TestediDC human immature myeloid dendritic cells
SpeciesHuman

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