Mouse/Rat Jak2 Alexa Fluor® 750-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Jak2

Janus Kinase 2 (Jak2) belongs to a family of protein tyrosine kinases that couple to cytokine receptors and are activated by ligand binding to these receptors. Activation of Jak2 and other family members Jak1, Jak3, and Tyk2 occurs via phosphorylation at two adjacent tyrosine residues as well as potentially one or more serine residues. Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites. Jak2 plays an essential role in interferon gamma signaling.

Product Datasheets

Related Research Areas

• Apoptosis Intracellular Kinases
• Chemokine Receptor Intracellular Signaling
• Epigenetics
• GDNF Family
• IL-10 Family
• IL-12 Family
• Interferons
• Intracellular Kinases
• Intracellular Kinases in the Akt Pathway
• Intracellular Signaling Molecules in Angiogenesis
• Jak and STAT Proteins
• Jak Kinases
• PDGF Family
• Search Kinases and Phosphatases
• Signaling Molecules and Transcriptional Regulators of Tfh Cell Differentiation
• Th17 Cells
• VEGF Family