Mouse TDRD1 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB6296S Datasheet / COA / SDS

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FAB6296S-100UG

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Mouse TDRD1 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse TDRD1 in direct ELISAs. In direct ELISAs, 100% cross-reactivity with recombinant human TDRD1 is observed.

Source

Monoclonal Rat IgG2a Clone # 739206

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant mouse TDRD1
Asn831-Lys960
Accession # Q99MV1

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: TDRD1

TDRD1 (Tudor domain containing protein 1; also MTR-1) is a 130-145 kDa member of the Tudor family of proteins. It is expressed in spermatocytes and spermatids, and forms part of an RNA-silencing complex that regulates gene expression. TDRD1, through its Tudor and MYND domains, binds methylated PIWI (P-element-induced wimpy testis) protein and PIWI-interacting RNA loading factor, respectively. This serves to promote the recruitment of germline-specific small RNAs into a PIWI ribonucleoprotein complex. Mouse TDRD1 is 1172 aa in length. It contains one MYND-type Zn finger region (aa 163-199), and four methyl-binding Tudor domains (aa 307-1032). Over aa 831-960, mouse TDRD1 shares 96% and 66% aa identity with rat and human TDRD1, respectively.

Long Name

Tudor Domain Containing 1

Entrez Gene IDs

56165 (Human); 83561 (Mouse); 292129 (Rat)

Alternate Names

CT41.1; CT41.1Cancer/testis antigen 41.1; FLJ21082; TDRD1; tudor domain containing 1; tudor domain containing protein 1; tudor domain-containing protein 1