MRS 2365

Name: MRS 2365
Brand: Tocris Bioscience
SKU: 2157
Price: 528 USD
Availability: InStock

Tocris Bioscience | Catalog # 2157

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Citations (92)

Product Documents

Highly potent and selective P2Y1 agonist

Product Description
Licensing Information
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Highly potent and selective P2Y1 agonist

View all P2Y Receptor Agonists »

Product Description

MRS 2365 is a highly potent, selective P2Y₁ receptor agonist (EC₅₀ = 0.4 nM). Displays no activity at P2Y₁₂ receptors and only very low agonist activity at P2Y₁₃ receptors (at concentrations up to 1 μM). Increases the upregulation of NTPDase1 by ATPγS.

Licensing Information

Sold under license from the NIH, US Patent 10/169975

Product Specifications for MRS 2365

Molecular Weight

549.28

Formula

C₁₃H₁₆N₅O₉P₂SNa₃

Storage

Store at -80°C

Purity

≥98% (HPLC)

Chemical Name

[[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt

PubChem ID

73755043

InChI Key

ZYPJOXVKTCEBCA-PVMCGCOJSA-K

SMILES

[Na+].[Na+].[Na+].CSC1=NC(N)=C2N=CN(C3[C@H]4C[C@@]4(COP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 92 publications citing the usage of this product.

Chhatriwala Induction of novel agonist selectivity for the ADP-activated P2Y₁ receptor versus the ADP-activated P2Y₁₂ and P2Y₁₃ receptors by conformational constraint of an ADP analog. J.Pharmacol.Exp.Ther. 2004 PMID: 15345752
Lu Stimulation of the P2Y₁ receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17626796
Ravi Adenine nucleotide analogues locked in a northern methanocarba conformation: enhanced stability and potency as P2Y₁ receptor agonists. J.Med.Chem. 2002 PMID: 11985476

Product Documents for MRS 2365

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for MRS 2365

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Citations for MRS 2365

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