Highly potent, selective P2Y1
receptor agonist (EC50
= 0.4 nM). Displays no activity at P2Y12
receptors and only very low agonist activity at P2Y13
receptors (at concentrations up to 1 μ
M). Increases the upregulation of NTPDase1 by ATPγ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from the NIH, US Patent 10/169975
Adenine nucleotide analogues locked in a northern methanocarba conformation: enhanced stability and potency as P2Y1 receptor agonists.
Ravi et al.
Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.
Chhatriwala et al.
Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells.
Lu et al.
The citations listed below are publications that use Tocris products. Selected citations for MRS 2365 include:
Showing Results 1 - 9 of 9