MRS 2365

  ( 9 citations )    
Product Datasheet
Catalog Number:2157
Chemical Name:[[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt
Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity
Highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM). Displays no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 μM). Increases the upregulation of NTPDase1 by ATPγS.
Technical Data
  • M.Wt:
    549.28
  • Formula:
    C13H16N5O9P2SNa3
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    436847-09-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the NIH, US Patent 10/169975
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for MRS 2365 include:

9 Citations: Showing 1 - 9
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  1. Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex.
    Authors: Koch Et al.
    J Cereb Blood Flow Metab  2015;40:305
  2. RASA3 is a critical inhibitor of RAP1-dependent platelet activation.
    Authors: Stefanini Et al.
    J Neurosci  2015;125:1419
  3. Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles.
    Authors: Kurahashi Et al.
    Am J Physiol Cell Physiol  2014;307:C561
  4. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    J Cereb Blood Flow Metab  2013;9:31
  5. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    Neuropsychopharmacology  2013;305:F396
  6. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol  2013;305:C1050
  7. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia.
    Authors: Kuboyama Et al.
    J Clin Invest  2011;31:1930
  8. The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons.
    Authors: Filippov Et al.
    Pharmacol Res  2010;30:11068
  9. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.
    Authors: Mamedova Et al.
    Purinergic Signal  2008;58:232

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