Muscleblind-like 1 Antibody

Novus Biologicals | Catalog # NBP1-06990

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all Muscleblind-like 1 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-SAEHLTSHKYVTQ corresponding to C-Terminus according to NP_997175.1, NP_997176.1, NP_997177.1, NP_997178.1, NP_997179.1, NP_997180.1.

Epitope

C Terminus

Specificity

This antibody is expected to recognize the reported isoforms (NP_066368.2; NP_997175.1; NP_997176.1; NP_997177.1; NP_997178.1; NP_997179.1)

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Muscleblind-like 1 Antibody

Western Blot: Muscleblind-like 1 Antibody [NBP1-06990]

Western Blot: Muscleblind-like 1 Antibody [NBP1-06990]

Western Blot: Muscleblind-like 1 Antibody [NBP1-06990] (1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Muscleblind-like 1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:4000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 45 kDa band observed in HeLa lysates (calculated MW of 41.8 kDa band according to NP_997176.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Muscleblind-like 1

Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus, being triplet repeat expansion dsRNA-binding proteins.

Alternate Names

DKFZp686P06174, EXP40, EXP42, EXPKIAA0428EXP35, MBNL, muscleblind (Drosophila)-like, muscleblind-like (Drosophila), muscleblind-like protein 1, Triplet-expansion RNA-binding protein

Entrez Gene IDs

4154 (Human); 56758 (Mouse); 282635 (Rat)

Gene Symbol

MBNL1

UniProt

NP_066368.2 (Human)

Additional Muscleblind-like 1 Products

Product Documents for Muscleblind-like 1 Antibody

Certificate of Analysis

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Product Specific Notices for Muscleblind-like 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Muscleblind-like 1 Antibody

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