The standard selective 5-HT1A
agonist. Also has moderate affinity for 5-HT7
is 6.6 at the human 5-HT7
receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo
. (R)-(+)-8-Hydroxy-DPAT hydrobromide
(Cat. No. 1080) and 7-Hydroxy-DPAT hydrobromide
(Cat. No. 0706) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Alteration of in-vitro 5-HT receptor pharmacology as a function of multiple treatment with 5-hydroxytryptamine of 8-hydroxy-2-(di-N-propylamino)tetralin in rat isolated aorta, uterus and fundus, and guinea pig isolated trachea.
Helton and Colbert
8-OH-DPAT discriminates between subtypes of the 5HT1 recognition site.
Middlemiss et al.
Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats.
Yoshitake and Kehr
Life Sci., 2004;74:2865
Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor.
Wood et al.
The citations listed below are publications that use Tocris products. Selected citations for 8-Hydroxy-DPAT hydrobromide include:
Showing Results 1 - 10 of 18