8-Hydroxy-DPAT hydrobromide

  ( 24 citations )    
Product Datasheet
Catalog Number:0529
Alternate Names:8-OH-DPAT hydrobromide
Chemical Name:(±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide
Product Details
Citations (24)
Supplemental Products
Reviews
Biological Activity
The standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo.

R-enantiomer and 7-Hydroxy Isomer also available..

Technical Data
  • M.Wt:
    328.29
  • Formula:
    C16H25NO.HBr
  • Solubility:
    Soluble to 20 mM in water with gentle warming
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    76135-31-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 8-Hydroxy-DPAT hydrobromide include:

24 Citations: Showing 1 - 10
Filter your results:

  1. Serotonin regulates prostate growth through androgen receptor modulation.
    Authors: Carvalho-Dias
    Sci Rep  2017;7(1):15428
  2. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
    Authors: Majeed Et al.
    Neural Plast  2016;2016:7291438
  3. Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity.
    Authors: Shelton Et al.
    Front Behav Neurosci  2015;8:453
  4. Sarpogrelate, a 5-HT2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy.
    Authors: Tullis Et al.
    Eur J Neurosci  2015;56:4560
  5. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    Invest Ophthalmol Vis Sci  2015;3:e00103
  6. N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.
    Authors: Richardson and Shelton
    Cell Signal  2015;352:156
  7. Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.
    Authors: Bonchak Et al.
    Arch Biochem Biophys  2014;563:71
  8. Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders.
    Authors: Khatri Et al.
    Psychopharmacology (Berl)  2014;231:1191
  9. GPER1 stimulation alters posttranslational modification of RGSz1 and induces desensitization of 5-HT1A receptor signaling in the rat hypothalamus.
    Authors: McAllister Et al.
    Neuroendocrinology  2014;100:228
  10. Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running.
    Authors: Fuss Et al.
    Synapse  2013;67:648
  11. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis.
    Authors: Araragi Et al.
    Front Pharmacol  2013;4:97
  12. The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.
    Authors: Borroto-Escuela Et al.
    J Neurosci  2012;32:6295
  13. Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole.
    Authors: Ishima Et al.
    Transl Psychiatry  2012;2:e170
  14. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.
    Authors: Rock Et al.
    Br J Pharmacol  2012;165:2620
  15. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
    Authors: Murray Et al.
    J Neurophysiol  2011;106:925
  16. 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians.
    Authors: Rawls Et al.
    Neurosci Lett  2010;484:113
  17. Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice.
    Authors: Hensler Et al.
    Psychoneuroendocrinology  2010;35:469
  18. Estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the hypothalamus is independent of estrogen receptor-beta.
    Authors: Rossi Et al.
    Psychoneuroendocrinology  2010;35:1023
  19. The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
    Authors: Duncan Et al.
    J Pharmacol Exp Ther  2010;31:1646
  20. Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice.
    Authors: Manzke Et al.
    J Clin Invest  2010;120:4118
  21. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One  2009;4:e6453
  22. Serotonin targets inhibitory synapses to induce modulation of network functions.
    Authors: Manzke Et al.
    Philos Trans R Soc Lond B Biol Sci  2009;364:2589
  23. Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.
    Authors: Pagano Et al.
    J Neurosci  2008;20:1190
  24. Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development.
    Authors: Maciag Et al.
    Brain Res  2006;1125:171
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Tocris Small Molecules
Description Application Cat# Citations Images  

(R)-(+)-8-Hydroxy-DPAT hydrobromide

1080 3  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human 5-HT1A (NP_000515) VersaClone cDNA

RDC0283
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human 5-HT7 (NP_062874) VersaClone cDNA

RDC0252
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human 5-HT7 (NP_000863) VersaClone cDNA

RDC0251
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Have you used 8-Hydroxy-DPAT hydrobromide?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee