Catalog Number: 0529
Alternate Names: 8-OH-DPAT hydrobromide
Chemical Name: (±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide
Biological Activity
The standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. (R)-(+)-8-Hydroxy-DPAT hydrobromide (Cat. No. 1080) and 7-Hydroxy-DPAT hydrobromide (Cat. No. 0706) also available.
Technical Data
  • M.Wt:
    328.29
  • Formula:
    C16H25NO.HBr
  • Solubility:
    Soluble to 20 mM in water with gentle warming
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    76135-31-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Alteration of in-vitro 5-HT receptor pharmacology as a function of multiple treatment with 5-hydroxytryptamine of 8-hydroxy-2-(di-N-propylamino)tetralin in rat isolated aorta, uterus and fundus, and guinea pig isolated trachea.
    Helton and Colbert
    J.Pharm.Pharmacol., 1994;46:902
  2. 8-OH-DPAT discriminates between subtypes of the 5HT1 recognition site.
    Middlemiss et al.
    Eur.J.Pharmacol., 1983;90:151
  3. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats.
    Yoshitake and Kehr
    Life Sci., 2004;74:2865
  4. Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor.
    Wood et al.
    Eur.J.Pharmacol., 2000;396:1
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 8-Hydroxy-DPAT hydrobromide include:

18 Citations: Showing 1 - 10
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  1. Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity.
    Authors: Shelton Et al.
    Front Behav Neurosci 2015;8:453
  2. Sarpogrelate, a 5-HT2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy.
    Authors: Tullis Et al.
    Eur J Neurosci 2015;56:4560
  3. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    Invest Ophthalmol Vis Sci 2015;3:e00103
  4. N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.
    Authors: Richardson and Shelton
    Cell Signal 2015;352:156
  5. Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders.
    Authors: Khatri Et al.
    Psychopharmacology (Berl) 2014;231:1191
  6. Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running.
    Authors: Fuss Et al.
    Synapse 2013;67:648
  7. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis.
    Authors: Araragi Et al.
    Front Pharmacol 2013;4:97
  8. The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.
    Authors: Borroto-Escuela Et al.
    J Neurosci 2012;32:6295
  9. Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole.
    Authors: Ishima Et al.
    Transl Psychiatry 2012;2:e170
  10. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.
    Authors: Rock Et al.
    Br J Pharmacol 2012;165:2620
  11. 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians.
    Authors: Rawls Et al.
    Neurosci Lett 2010;484:113
  12. Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice.
    Authors: Hensler Et al.
    Psychoneuroendocrinology 2010;35:469
  13. The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
    Authors: Duncan Et al.
    J Pharmacol Exp Ther 2010;31:1646
  14. Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice.
    Authors: Manzke Et al.
    J Clin Invest 2010;120:4118
  15. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One 2009;4:e6453
  16. Serotonin targets inhibitory synapses to induce modulation of network functions.
    Authors: Manzke Et al.
    Philos Trans R Soc Lond B Biol Sci 2009;364:2589
  17. Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.
    Authors: Pagano Et al.
    J Neurosci 2008;20:1190
  18. Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development.
    Authors: Maciag Et al.
    Brain Res 2006;1125:171
Expand to show all 18 Citations
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(R)-(+)-8-Hydroxy-DPAT hydrobromide

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