NBQX disodium salt

Tocris Bioscience | Catalog # 1044

Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)
Tocris Bioscience

Key Product Details

Description

Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)
View all AMPA Receptor Antagonists »

Product Description

NBQX disodium salt is a selective and competitive AMPA and kainate receptor antagonist (IC50 = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.

NBQX disodium salt is a more water-soluble form of NBQX (Cat. No. 0373).

Licensing Information

Sold with the permission of Novo Nordisk A/S

Product Specifications for NBQX disodium salt

Molecular Weight

380.24

Formula

C12H6N4O6SNa2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt

CAS Number

479347-86-9

PubChem ID

3272523

InChI Key

SVJKYIUJRJEABK-UHFFFAOYSA-L

SMILES

[Na+].[Na+].NS(=O)(=O)C1=C2C(=CC=C1)C1=NC([O-])=C([O-])N=C1C=C2[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.01 50

Preparing Stock Solutions for NBQX disodium salt

The following data is based on the product molecular weight 380.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.26 mL 26.30 mL 52.60 mL
2.5 mM 1.05 mL 5.26 mL 10.52 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
25 mM 0.11 mL 0.53 mL 1.05 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 292 publications citing the usage of this product.

Product Documents for NBQX disodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NBQX disodium salt

For research use only

Citations for NBQX disodium salt

Customer Reviews for NBQX disodium salt (3)

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  • Suppression of AMPA receptors
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Cerebellum
    Verified Customer | Posted 06/21/2023
    Needs sonication for dilution
    NBQX disodium salt was used as a control to demonstrate pharmacological isolation of AMPAR-generated whole-cell electrophysiological response. Top trace: response to rapidly applied AMPA. Bottom trace: response to AMPA+NBQX.
    NBQX disodium salt 1044
  • The best option to block AMPA receptors
    Name: Luiz Alexandre Magno
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 06/20/2018
    Always make fresh solutions
    I infused the NBQX disodium salt (22 mM) into mouse brain to block AMPA receptors in the striatum. This was done by using an internal infusion cannula. The disodium salt is the best choice for this kind of experiment because it is soluble in aqueous solutions such as NaCl 0.9%. NBQX is more specific and potent than DNQX.
  • Excellent AMPA receptor antagonist
    Name: Andy Gao
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 01/13/2018
    Aliquot properly in dMSO
    Used in extracellular bath solution during electrophysiology of hippocampal neuron culture to block glutamatergic AMPA receptors to isolate NMDA receptor currents.
    NBQX disodium salt 1044

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