NBQX disodium salt

Catalog # Availability Size / Price Qty
1044/10
1044/50
1044/1
NBQX disodium salt | CAS No. 479347-86-9 | AMPA Receptor Antagonists
1 Image
Description: Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)

Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt

Purity: ≥98%

Product Details
Citations (36)
Supplemental Products
Reviews (2)

Biological Activity

Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo. More water soluble disodium salt of NBQX (Cat. No. 0373).

Technical Data

M.Wt:
380.24
Formula:
C12H6N4O6SNa2
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
479347-86-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Novo Nordisk A/S

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for NBQX disodium salt

The citations listed below are publications that use Tocris products. Selected citations for NBQX disodium salt include:

36 Citations: Showing 1 - 10

  1. Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model.
    Authors: Kiritoshi and Neugebauer
    ACS Chem Neurosci  2018;9:2252
  2. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
    Authors: Collins Et al.
    Neuron  2018;98:366
  3. OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons.
    Authors: Xiao Et al.
    Elife  2018;7
  4. Potassium channels contribute to activity-dependent regulation of dendritic inhibition.
    Authors: Chang and Higley
    Physiol Rep  2018;6:e13747
  5. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
    Authors: Purkey Et al.
    Cell Rep  2018;25:974
  6. Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex.
    Authors: Sancho and Bloodgood
    Cell Rep  2018;24:2075
  7. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
    Authors: Beas Et al.
    Nat Neurosci  2018;21:963
  8. The THO Complex Coordinates Transcripts for Synapse Development and DA Neuron Survival.
    Authors: Maeder Et al.
    Cell  2018;174:1436
  9. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
    Authors: Fan Et al.
    Nat Methods  2018;15:823
  10. Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
    Authors: Lai Et al.
    Neuron  2017;95:591
  11. Biased OXTergic Modulation of Midbrain DA Systems.
    Authors: Xiao Et al.
    Neuron  2017;95:368
  12. Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala.
    Authors: Kim and Cho
    Neuron  2017;95:1129
  13. Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.
    Authors: Sigler Et al.
    Neuron  2017;94:304
  14. A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
    Authors: Li Et al.
    Neuron  2017;94:1155
  15. Rods progressively escape saturation to drive visual responses in daylight conditions.
    Authors: Tikidji-Hamburyan Et al.
    Nat Commun  2017;8:1813
  16. Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.
    Authors: Hull
    Cold Spring Harb Protoc  2017;2017
  17. Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour.
    Authors: Liu Et al.
    Nature  2016;538:383
  18. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
    Authors: O'Donnell Et al.
    J Neurosci  2016;36:7109
  19. Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
    Authors: Malvaez Et al.
    PLoS One  2015;5:12511
  20. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    Sci Rep  2015;35:5680
  21. Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex.
    Authors: Tsutsui-Kimura Et al.
    Neuron  2015;18
  22. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Neurochem Int  2015;10:e0131430
  23. Step-by-step instructions for retina recordings with perforated multi electrode arrays.
    Authors: Reinhard Et al.
    PLoS One  2014;9:e106148
  24. Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex.
    Authors: Bortone Et al.
    J Neurosci  2014;82:474
  25. A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.
    Authors: Crook Et al.
    Vis Neurosci  2014;31:57
  26. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition.
    Authors: Bloodgood Et al.
    Nature  2013;503:121
  27. Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition.
    Authors: He Et al.
    Int J Neuropsychopharmacol  2013;109:1535
  28. Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury.
    Authors: Gensel Et al.
    J Neurosci  2012;7:e33519
  29. Gain control by layer six in cortical circuits of vision.
    Authors: Olsen Et al.
    J Neurophysiol  2012;483:47
  30. Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
    Authors: Carlson Et al.
    Brain Behav  2012;2:391
  31. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
    Authors: Butti Et al.
    Brain  2012;135:3320
  32. SAP102 is a highly mobile MAGUK in spines.
    Authors: Zheng Et al.
    J Neurosci  2010;30:4757
  33. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
    Authors: Shin Et al.
    J Cereb Blood Flow Metab  2006;26:1018
  34. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.
    Authors: Harkany Et al.
    PLoS One  2004;24:4978
  35. Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.
    Authors: Ronesi Et al.
    J Neurosci  2004;24:1673
  36. Astrocyte-mediated activation of neuronal kainate receptors.
    Authors: Liu Et al.
    Nature  2004;101:3172

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Tocris Small Molecules

Reviews for NBQX disodium salt

Average Rating: 5 (Based on 2 Reviews)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used NBQX disodium salt?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


The best option to block AMPA receptors
By Luiz Alexandre Magno on 06/20/2018
Species: Mouse

I infused the NBQX disodium salt (22 mM) into mouse brain to block AMPA receptors in the striatum. This was done by using an internal infusion cannula. The disodium salt is the best choice for this kind of experiment because it is soluble in aqueous solutions such as NaCl 0.9%. NBQX is more specific and potent than DNQX.

PMID: 28436980

Excellent AMPA receptor antagonist
By Andy Gao on 01/13/2018
Species: Mouse

Used in extracellular bath solution during electrophysiology of hippocampal neuron culture to block glutamatergic AMPA receptors to isolate NMDA receptor currents.


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.