Catalog Number: 1044
Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt
Biological Activity
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo. More water soluble disodium salt of NBQX (Cat. No. 0373). Also available as part of the AMPA Receptor Tocriset™.
Technical Data
  • M.Wt:
    380.24
  • Formula:
    C12H6N4O6SNa2
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    479347-86-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novo Nordisk A/S
Background References
  1. The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model.
    Gill et al.
    Brain Res., 1992;580:35
  2. Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy.
    Namba et al.
    Brain Res., 1994;638:36
  3. The pharmacology of AMPA receptors and their antagonists.
    Sheardown et al.
    Stroke, 1993;24:146
  4. Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro.
    Zeman and Lodg
    Br.J.Pharmacol., 1992;106:367
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NBQX disodium salt include:

16 Citations: Showing 1 - 10
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  1. Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
    Authors: Malvaez Et al.
    PLoS One 2015;5:12511
  2. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    Sci Rep 2015;35:5680
  3. Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex.
    Authors: Tsutsui-Kimura Et al.
    Neuron 2015;18
  4. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Neurochem Int 2015;10:e0131430
  5. Step-by-step instructions for retina recordings with perforated multi electrode arrays.
    Authors: Reinhard Et al.
    PLoS One 2014;9:e106148
  6. Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex.
    Authors: Bortone Et al.
    J Neurosci 2014;82:474
  7. A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.
    Authors: Crook Et al.
    Vis Neurosci 2014;31:57
  8. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition.
    Authors: Bloodgood Et al.
    Nature 2013;503:121
  9. Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition.
    Authors: He Et al.
    Int J Neuropsychopharmacol 2013;109:1535
  10. Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury.
    Authors: Gensel Et al.
    J Neurosci 2012;7:e33519
  11. Gain control by layer six in cortical circuits of vision.
    Authors: Olsen Et al.
    J Neurophysiol 2012;483:47
  12. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
    Authors: Butti Et al.
    Brain 2012;135:3320
  13. SAP102 is a highly mobile MAGUK in spines.
    Authors: Zheng Et al.
    J Neurosci 2010;30:4757
  14. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
    Authors: Shin Et al.
    J Cereb Blood Flow Metab 2006;26:1018
  15. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.
    Authors: Harkany Et al.
    PLoS One 2004;24:4978
  16. Astrocyte-mediated activation of neuronal kainate receptors.
    Authors: Liu Et al.
    Nature 2004;101:3172
Expand to show all 16 Citations
Tocris Small Molecules
Description Application Cat# Citations Images  

NBQX

0373 143  
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