NBQX disodium salt
Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt
Biological ActivityNBQX disodium salt is a selective and competitive AMPA and kainate receptor antagonist (IC50 = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.
NBQX disodium salt is a more water-soluble form of NBQX (Cat. No. 0373).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model.
Gill et al.
Brain Res., 1992;580:35
Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy.
Namba et al.
Brain Res., 1994;638:36
The pharmacology of AMPA receptors and their antagonists.
Sheardown et al.
Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro.
Zeman and Lodg
Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test
Yoon et al.
J.Korean Med.Sci., 2005;20:307
Citations for NBQX disodium salt
The citations listed below are publications that use Tocris products. Selected citations for NBQX disodium salt include:
42 Citations: Showing 1 - 10
Multi-target action of β-alanine protects cerebellar tissue from ischemic damage.
Authors: Kopach Et al.
Cell Death Dis 2022;13:747
Oxytocin shapes spontaneous activity patterns in the developing visual cortex by activating somatostatin interneurons.
Authors: Maldonado Et al.
Curr Biol 2021;31:322
Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release.
Authors: Kramer Et al.
TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations
Authors: O'Malley Et al.
J Neurosci 2020;40:4813
Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons.
Authors: Evans Et al.
Cell Rep 2020;32
Hippocampal hub neurons maintain distinct connectivity throughout their lifetime.
Authors: Bocchio Et al.
Nat Commun 2020;11:4559
Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model.
Authors: Kiritoshi and Neugebauer
ACS Chem Neurosci 2018;9:2252
Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
Authors: Collins Et al.
OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons.
Authors: Xiao Et al.
Potassium channels contribute to activity-dependent regulation of dendritic inhibition.
Authors: Chang and Higley
Physiol Rep 2018;6:e13747
AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
Authors: Purkey Et al.
Cell Rep 2018;25:974
Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex.
Authors: Sancho and Bloodgood
Cell Rep 2018;24:2075
The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
Authors: Beas Et al.
Nat Neurosci 2018;21:963
The THO Complex Coordinates Transcripts for Synapse Development and DA Neuron Survival.
Authors: Maeder Et al.
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
Authors: Fan Et al.
Nat Methods 2018;15:823
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
Authors: Lai Et al.
Biased OXTergic Modulation of Midbrain DA Systems.
Authors: Xiao Et al.
Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala.
Authors: Kim and Cho
Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.
Authors: Sigler Et al.
A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
Authors: Li Et al.
Rods progressively escape saturation to drive visual responses in daylight conditions.
Authors: Tikidji-Hamburyan Et al.
Nat Commun 2017;8:1813
Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.
Cold Spring Harb Protoc 2017;2017
Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour.
Authors: Liu Et al.
Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
Authors: O'Donnell Et al.
J Neurosci 2016;36:7109
Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
Authors: Malvaez Et al.
PLoS One 2015;5:12511
Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
Authors: Liu Et al.
Sci Rep 2015;35:5680
Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex.
Authors: Tsutsui-Kimura Et al.
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
Neurochem Int 2015;10:e0131430
Step-by-step instructions for retina recordings with perforated multi electrode arrays.
Authors: Reinhard Et al.
PLoS One 2014;9:e106148
Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex.
Authors: Bortone Et al.
J Neurosci 2014;82:474
A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.
Authors: Crook Et al.
Vis Neurosci 2014;31:57
The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition.
Authors: Bloodgood Et al.
Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition.
Authors: He Et al.
Int J Neuropsychopharmacol 2013;109:1535
Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury.
Authors: Gensel Et al.
J Neurosci 2012;7:e33519
Gain control by layer six in cortical circuits of vision.
Authors: Olsen Et al.
J Neurophysiol 2012;483:47
Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
Authors: Carlson Et al.
Brain Behav 2012;2:391
Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
Authors: Butti Et al.
SAP102 is a highly mobile MAGUK in spines.
Authors: Zheng Et al.
J Neurosci 2010;30:4757
Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
Authors: Shin Et al.
J Cereb Blood Flow Metab 2006;26:1018
Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.
Authors: Harkany Et al.
PLoS One 2004;24:4978
Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.
Authors: Ronesi Et al.
J Neurosci 2004;24:1673
Astrocyte-mediated activation of neuronal kainate receptors.
Authors: Liu Et al.
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