Catalog Number: 1199
Chemical Name: 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Biological Activity
A potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases.
Technical Data
  • M.Wt:
    1401.1
  • Formula:
    C49H30N6Na6O23S6
  • Solubility:
    Soluble to 25 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    202983-32-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antagonism by the suramin analogue NF 279 on human P2X1 and P2X7 receptors.
    Klapperstuck et al.
    Eur.J.Pharmacol., 2000;387:245
  2. NF279: a novel potent and selective antagonist of P2X receptor-mediated responses.
    Damer et al.
    Eur.J.Pharmacol., 1998;350:R5
  3. The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor.
    Rettinger et al.
    Neuropharmacology, 2000;39:2044
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NF 279 include:

8 Citations: Showing 1 - 8
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  1. High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors.
    Authors: Aliagas Et al.
    PLoS One 2014;2014:509027
  2. Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis".
    Authors: Aliagas Et al.
    Purinergic Signal 2013;9:599
  3. Purinergic receptors are required for HIV-1 infection of primary human macrophages.
    Authors: Hazleton Et al.
    J Immunol 2012;188:4488
  4. A high throughput scintillation proximity imaging assay for protein methyltransferases.
    Authors: Ibáñez Et al.
    Comb Chem High Throughput Screen 2012;15:359
  5. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
    Authors: Donnelly-Roberts Et al.
    Br J Pharmacol 2009;157:1203
  6. UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation.
    Authors: Luke and Hexum
    Mediators Inflamm 2008;4:323
  7. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
    Authors: Kennedy Et al.
    J Neurosci 2007;27:845
  8. Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior.
    Authors: Inscho Et al.
    J Clin Invest 2003;112:1895

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