Chemical Name: 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Biological ActivityNF 279 is a a potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
NF279: a novel potent and selective antagonist of P2X receptor-mediated responses.
Damer et al.
Antagonism by the suramin analogue NF 279 on human P2X1 and P2X7 receptors.
Klapperstuck et al.
The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor.
Rettinger et al.
Citations for NF 279
The citations listed below are publications that use Tocris products. Selected citations for NF 279 include:
9 Citations: Showing 1 - 9
The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
Authors: Nishimura Et al.
PLoS Pathog 2015;11:e1005184
High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors.
Authors: Aliagas Et al.
PLoS One 2014;2014:509027
Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis".
Authors: Aliagas Et al.
Purinergic Signal 2013;9:599
Purinergic receptors are required for HIV-1 infection of primary human macrophages.
Authors: Hazleton Et al.
J Immunol 2012;188:4488
A high throughput scintillation proximity imaging assay for protein methyltransferases.
Authors: Ibáñez Et al.
Comb Chem High Throughput Screen 2012;15:359
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
Authors: Donnelly-Roberts Et al.
Br J Pharmacol 2009;157:1203
UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation.
Authors: Luke and Hexum
Mediators Inflamm 2008;4:323
Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
Authors: Kennedy Et al.
J Neurosci 2007;27:845
Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior.
Authors: Inscho Et al.
J Clin Invest 2003;112:1895
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