NF 279

  ( 9 citations )    
Product Datasheet
Catalog Number:1199
Chemical Name:8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Product Details
Citations (9)
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Biological Activity
A potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases.
Technical Data
  • M.Wt:
    1401.1
  • Formula:
    C49H30N6Na6O23S6
  • Solubility:
    Soluble to 25 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    202983-32-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NF 279 include:

9 Citations: Showing 1 - 9
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  1. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
    Authors: Nishimura Et al.
    PLoS Pathog  2015;11:e1005184
  2. High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors.
    Authors: Aliagas Et al.
    PLoS One  2014;2014:509027
  3. Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis".
    Authors: Aliagas Et al.
    Purinergic Signal  2013;9:599
  4. Purinergic receptors are required for HIV-1 infection of primary human macrophages.
    Authors: Hazleton Et al.
    J Immunol  2012;188:4488
  5. A high throughput scintillation proximity imaging assay for protein methyltransferases.
    Authors: Ibáñez Et al.
    Comb Chem High Throughput Screen  2012;15:359
  6. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
    Authors: Donnelly-Roberts Et al.
    Br J Pharmacol  2009;157:1203
  7. UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation.
    Authors: Luke and Hexum
    Mediators Inflamm  2008;4:323
  8. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
    Authors: Kennedy Et al.
    J Neurosci  2007;27:845
  9. Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior.
    Authors: Inscho Et al.
    J Clin Invest  2003;112:1895

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