Catalog Number: 1199
Chemical Name: 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Biological Activity
A potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antagonism by the suramin analogue NF 279 on human P2X1 and P2X7 receptors.
    Klapperstuck et al.
    Eur.J.Pharmacol., 2000;387:245
  2. NF279: a novel potent and selective antagonist of P2X receptor-mediated responses.
    Damer et al.
    Eur.J.Pharmacol., 1998;350:R5
  3. The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor.
    Rettinger et al.
    Neuropharmacology, 2000;39:2044
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