NF 449

Tocris Bioscience | Catalog # 1391

Highly selective P2X1 antagonist
Tocris Bioscience

Key Product Details

Description

Highly selective P2X1 antagonist
View all P2X Receptor Antagonists »

Product Description

NF 449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Provides antithrombotic protection in vivo. Also acts as a Gsα-selective antagonist. Also inhibits DNA-binding activity of HMGA2 (IC50 = 0.43 μM).

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.

Product Specifications for NF 449

Molecular Weight

1505.06

Formula

C41H24N6Na8O29S8

Storage

Store at RT

Purity

≥90% (HPLC)

Chemical Name

4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid, octasodium salt

CAS Number

627034-85-9

PubChem ID

91895233

InChI Key

PHCBPKWKKHYRSA-UHFFFAOYSA-F

SMILES

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC=C(NC(=O)C2=CC(=CC(NC(=O)NC3=CC(=CC(=C3)C(=O)NC3=CC=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)C(=O)NC3=CC=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)=C2)C(=O)NC2=CC=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)C(=C1)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25 17

Preparing Stock Solutions for NF 449

The following data is based on the product molecular weight 1505.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.17 mM 3.91 mL 19.54 mL 39.08 mL
0.85 mM 0.78 mL 3.91 mL 7.82 mL
1.7 mM 0.39 mL 1.95 mL 3.91 mL
8.5 mM 0.08 mL 0.39 mL 0.78 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Product Documents for NF 449

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NF 449

For research use only

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