Potent purinergic receptor antagonist that displays high selectivity for P2X1
values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1
receptors respectively). Provides antithrombotic protection in vivo
. Also acts as a Gsα
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All Tocris products are intended for laboratory research use only.
Inhibition of platelet functions and thrombosis through selective or non-selective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4",4'"-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benze
Hechler et al.
Gsα-selective G protein antagonists.
Hohenegger et al.
Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist.
Rettinger et al.
Chemical modulators of autophagy as biological probes and potential therapeutics.
Fleming et al.
The citations listed below are publications that use Tocris products. Selected citations for NF 449 include:
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