NF 449

  ( 13 citations )    
Product Datasheet
Catalog Number:1391
Chemical Name:4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid, octasodium salt
Product Details
Citations (13)
Supplemental Products
Reviews
Biological Activity
Potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Provides antithrombotic protection in vivo. Also acts as a Gsα-selective antagonist.
Technical Data
  • M.Wt:
    1505.06
  • Formula:
    C41H24N6Na8O29S8
  • Solubility:
    Soluble to 50 mM in water with gentle warming
  • Storage:
    Store at RT
  • CAS No:
    627034-85-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NF 449 include:

13 Citations: Showing 1 - 10
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  1. Optodynamic simulation of β-adrenergic receptor signalling.
    Authors: Siuda Et al.
    Purinergic Signal  2015;6:8480
  2. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
    Authors: Nishimura Et al.
    PLoS Pathog  2015;11:e1005184
  3. Effects of NAD at purine receptors in isolated blood vessels.
    Authors: Alefishat Et al.
    Circulation  2015;11:47
  4. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.
    Authors: Ren Et al.
    Emerg Microbes Infect  2014;3:e62
  5. The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma.
    Authors: He Et al.
    Nat Med  2014;20:1035
  6. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.
    Authors: Madoux Et al.
    Biopolymers  2014;102:396
  7. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol  2013;305:C1050
  8. Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7.
    Authors: Vergani Et al.
    Integr Biol (Camb)  2013;127:463
  9. A high throughput scintillation proximity imaging assay for protein methyltransferases.
    Authors: Ibáñez Et al.
    Comb Chem High Throughput Screen  2012;15:359
  10. Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system.
    Authors: Cheng Et al.
    Mol Endocrinol  2011;25:1624
  11. P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions.
    Authors: Maloney Et al.
    Lipids Health Dis  2010;2:183
  12. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
    Authors: Donnelly-Roberts Et al.
    Br J Pharmacol  2009;157:1203
  13. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.
    Authors: Kennedy Et al.
    J Neurosci  2007;27:845
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