Cyclin-dependent kinase 2 (cdk2) inhibitor; induces cell-cycle arrest at the G2
-M phase. 10- to 36-fold more selective for cdk2-cyclin A over other cdks (IC50
= 0.41 μ
M for cdk2-cyclin A). Potentiates the apoptotic effect of taxol
(Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin.
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Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
Pennati, M et al.
Mol Cancer Ther;4(9):1328-37.