NU 6140

Catalog # Availability Size / Price Qty
NU 6140 | CAS No. 444723-13-1 | Cyclin-dependent Kinase Inhibitors
1 Image
Description: Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

Chemical Name: 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide

Purity: ≥99%

Product Details
Citations (4)

Biological Activity

NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor (IC50 values are 0.42 - 1.1 μM). Displays some selectivity for cdk2 (IC50 value = 0.94 μM for cdk4 and >2.3 μM for other cdks). Induces cell-cycle arrest at the G2-M phase. Potentiates the apoptotic effect of taxol (Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin. Also potently inhibits aurora kinases (IC50 values are 0.035 and 0.067 μM for aurora kinase B and A, respectively).

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for NU 6140

The citations listed below are publications that use Tocris products. Selected citations for NU 6140 include:

4 Citations: Showing 1 - 4


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for NU 6140

There are currently no reviews for this product. Be the first to review NU 6140 and earn rewards!

Have you used NU 6140?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.