Chemical Name: 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide
Biological ActivityNU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor (IC50 values are 0.42 - 1.1 μM). Displays some selectivity for cdk2 (IC50 value = 0.94 μM for cdk4 and >2.3 μM for other cdks). Induces cell-cycle arrest at the G2-M phase. Potentiates the apoptotic effect of taxol (Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin. Also potently inhibits aurora kinases (IC50 values are 0.035 and 0.067 μM for aurora kinase B and A, respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
Potentiation of PacT.-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
Pennati et al.
Citations for NU 6140
The citations listed below are publications that use Tocris products. Selected citations for NU 6140 include:
4 Citations: Showing 1 - 4
Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.
Authors: Musa Et al.
Nat Commun 2019;10:4128
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
Authors: Berenjeno Et al.
Nat Commun 2017;8:1773
miR-200b induces cell cycle arrest and represses cell growth in esophageal squamous cell carcinoma.
Authors: Zhang Et al.
Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.
Authors: Boekhout Et al.
EMBO Rep 2016;17:414
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