O-1602

Catalog # Availability Size / Price Qty
2797/10
O-1602 | CAS No. 317321-41-8 | GPR55 Receptor Agonists
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Description: Potent GPR55 agonist

Chemical Name: 5-Methyl-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol

Purity: ≥97%

Product Details
Citations (10)
Supplemental Products
Reviews (1)

Biological Activity

Analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, > 30000 and > 30000 nM for GPR55, CB1 and CB2 receptors respectively). Induces activation of RhoA, cdc42 and rac1. Increases proliferation of neural stem cells NSCs in vitro and in vivo. Also promotes neurogenesis in vivo.

Technical Data

M.Wt:
258.36
Formula:
C17H22O2
Solubility:
Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
317321-41-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for O-1602

The citations listed below are publications that use Tocris products. Selected citations for O-1602 include:

10 Citations: Showing 1 - 10

  1. Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells.
    Authors: Schwartz Et al.
    Oncotarget  2018;9:34595
  2. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis.
    Authors: Hill Et al.
    Br.J.Pharmacol.  2018;175:3407
  3. Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells.
    Authors: Saliba Et al.
    J Neuroinflammation  2018;15:322
  4. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress.
    Authors: Shi
    Mol Brain  2017;10(1):38
  5. Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent.
    Authors: Hanlon Et al.
    Breast Cancer (Dove Med Press)  2016;8:59
  6. Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding
    Authors: Ailte Et al.
    Scientific Reports  2016;6:30336
  7. △(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.
    Authors: Williams Et al.
    Immunol Cell Biol  2014;9:369
  8. A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans.
    Authors: Romero-Zerbo Et al.
    J Endocrinol  2011;211:177
  9. The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.
    Authors: Schicho Et al.
    Inflamm Bowel Dis  2011;17:1651
  10. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.
    Authors: Daly Et al.
    Br J Pharmacol  2010;159:787

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O-1602 regulates PGE2 release
By Anonymous on 09/21/2019
Species: Mouse

O-1602 was used to study impact of GPR-55 on prostaglandin E2 release from hippocampal microglial cells. We found that O-1602 causes a clear, albeit not very mighty effect decreasing PGE2 release; concentrations higher than 50 microM did not display a significant difference from effect generated by 50 microM of O-1602.


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