Catalog # Availability Size / Price Qty
O-1602 | CAS No. 317321-41-8 | GPR55 Receptor Agonists
1 Image
Description: Potent GPR55 agonist

Chemical Name: 5-Methyl-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol

Purity: ≥97%

Product Details
Citations (10)
Supplemental Products

Biological Activity

O-1602 is an analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, > 30000 and > 30000 nM for GPR55, CB1 and CB2 receptors respectively). Induces activation of RhoA, cdc42 and rac1. Increases proliferation of neural stem cells NSCs in vitro and in vivo. Also promotes neurogenesis in vivo.

Technical Data

Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for O-1602

The citations listed below are publications that use Tocris products. Selected citations for O-1602 include:

10 Citations: Showing 1 - 10

  1. Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells.
    Authors: Schwartz Et al.
    Oncotarget  2018;9:34595
  2. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis.
    Authors: Hill Et al.
    Br.J.Pharmacol.  2018;175:3407
  3. Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells.
    Authors: Saliba Et al.
    J Neuroinflammation  2018;15:322
  4. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress.
    Authors: Shi
    Mol Brain  2017;10(1):38
  5. Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent.
    Authors: Hanlon Et al.
    Breast Cancer (Dove Med Press)  2016;8:59
  6. Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding
    Authors: Ailte Et al.
    Scientific Reports  2016;6:30336
  7. △(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.
    Authors: Williams Et al.
    Immunol Cell Biol  2014;9:369
  8. A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans.
    Authors: Romero-Zerbo Et al.
    J Endocrinol  2011;211:177
  9. The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.
    Authors: Schicho Et al.
    Inflamm Bowel Dis  2011;17:1651
  10. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.
    Authors: Daly Et al.
    Br J Pharmacol  2010;159:787


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for O-1602

There are currently no reviews for this product. Be the first to review O-1602 and earn rewards!

Have you used O-1602?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.