p120-catenin [p Ser268] Antibody

Novus Biologicals | Catalog # NBP3-12923

Novus Biologicals
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Key Product Details

Validated by

Knockout/Knockdown, Biological Validation

Species Reactivity

Validated:

Human, Mouse

Predicted:

Bovine (100%), Rat (100%), Rhesus Macaque (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all p120-catenin Primary Antibodies »

Product Specifications

Immunogen

Carrier-protein conjugated synthetic peptide surrounding phospho Ser268 of human p120-catenin. The exact sequence is proprietary.

Modification

p Ser 268

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Centrifuge briefly prior to opening.

Scientific Data Images for p120-catenin [p Ser268] Antibody

Western Blot: p120-catenin [p Ser268] Antibody [NBP3-12923]

Western Blot: p120-catenin [p Ser268] Antibody [NBP3-12923]

Western Blot: p120-catenin [p Ser268] Antibody [NBP3-12923] - Non-transfected (-) and transfected (+) A431 whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with p120-catenin (phospho Ser268) antibody (NBP3-12923) diluted at 1:3000.
Western Blot: p120-catenin [p Ser268] Antibody [NBP3-12923]

Western Blot: p120-catenin [p Ser268] Antibody [NBP3-12923]

Western Blot: p120-catenin [p Ser268] Antibody [NBP3-12923] - p120-catenin (phospho Ser268) antibody detects p120-catenin (phospho Ser268) protein by western blot analysis. Un-treated (-) and treated (+, CIP treatment) A431 whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with p120-catenin (phospho Ser268) antibody (NBP3-12923) diluted at 1:1000. (CIP: Calf-intestinal alkaline phosphatase)
Western Blot: p120-catenin [p Ser268] Antibody [NBP3-12923]

Western Blot: p120-catenin [p Ser268] Antibody [NBP3-12923]

Western Blot: p120-catenin [p Ser268] Antibody [NBP3-12923] - Various whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with p120-catenin (phospho Ser268) antibody (NBP3-12923) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.

Applications for p120-catenin [p Ser268] Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS, 1% BSA, 20% Glycerol

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: p120-catenin

The alpha, beta, delta, and gamma -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. alpha-catenin, a 102 kDa protein, interacts with E-cadherin associated protein, and also associates with other members of the cadherin family, such as N-cadherin and P-cadherin. The 92 kDa beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta-catenin also complexes with the tumor suppressor protein APC. delta-catenin interacts with Presenilin 1 and is expressed in the brain. The gene encoding delta-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding delta-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. gamma-catenin, also known as plakoglobin, is an 80-88 kDa protein that binds alpha-catenin and N-cadherin. In addition, the transmembrane phosphatase PTPm associates with catenin/cadherin complexes and may regulate complex signaling.

Alternate Names

Cadherin-associated Src substrate, CAS, catenin (cadherin-associated protein), delta 1, catenin delta-1, CTNND, KIAA0384P120CAS, p120, p120 catenin, p120(cas), p120(CTN), p120cas, p120ctn

Gene Symbol

CTNND1

Additional p120-catenin Products

Product Documents for p120-catenin [p Ser268] Antibody

Certificate of Analysis

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Product Specific Notices for p120-catenin [p Ser268] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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