Key Product Details

Species Reactivity

Human

Applications

Western Blot, Flow (Cell Surface), Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 186C426

Format

Azide and BSA Free
View all PGLYRP4/PGRP-I beta Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against KLH-conjugated synthetic peptide corresponding to amino acids 95-110 of human PGRP-1 beta.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for PGLYRP4/PGRP-I beta Antibody (186C426) - Azide and BSA Free

Western Blot: PGLYRP4/PGRP-I beta Antibody (186C426)Azide Free [NBP2-33246]

Western Blot: PGLYRP4/PGRP-I beta Antibody (186C426)Azide Free [NBP2-33246]

Western Blot: PGLYRP4/PGRP-I beta Antibody (186C426) - Azide Free [NBP2-33246] - Analysis in cell lysates from human brain using a dilution of 2 ug/ml.

Applications for PGLYRP4/PGRP-I beta Antibody (186C426) - Azide and BSA Free

Application
Recommended Usage

Flow (Cell Surface)

reported in scientific literature (Uehara et al (2005))

Immunocytochemistry/ Immunofluorescence

reported in scientific literature (Uehara et al (2005))

Western Blot

2 ug/ml

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PGLYRP4/PGRP-I beta

The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-I alpha, and PGRP-I beta) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4-5).

Long Name

Peptidoglycan Recognition Protein Intermediate, Beta/Peptidoglycan Recognition Protein 4

Alternate Names

Pglyrp-1 beta, PGRP-I beta, PGRPI beta

Gene Symbol

PGLYRP4

Additional PGLYRP4/PGRP-I beta Products

Product Documents for PGLYRP4/PGRP-I beta Antibody (186C426) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for PGLYRP4/PGRP-I beta Antibody (186C426) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Host Defense/Innate Immunity

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Protocols

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