PMP22 Antibody (Hu1) - Azide and BSA Free

Novus Biologicals | Catalog # NBP2-80913

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Bovine (Negative), Mouse (Negative), Primate, Rat (Negative)

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # Hu1

Format

Azide and BSA Free
View all PMP22 Primary Antibodies »

Product Specifications

Immunogen

Human PMP22 cDNA boosted with a 13-amino acid peptide of the 2nd extracellular domain (a.a. 120-133) conjugated to murine IgG. [Swiss-Prot# Q01453]

Epitope

Detects amino acids 121-123 in the second extracellular domain of human PMP22.

Reactivity Notes

Rhesus monkey. Does not react with mouse, rat, or bovine nerve protein.

Localization

Membrane

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for PMP22 Antibody (Hu1) - Azide and BSA Free

Immunohistochemistry: PMP22 Antibody (Hu1) - Azide and BSA Free [NBP2-80913]

Immunohistochemistry: PMP22 Antibody (Hu1) - Azide and BSA Free [NBP2-80913]

Immunohistochemistry: PMP22 Antibody (Hu1) - Azide and BSA Free [NBP2-80913] - Staining of PMP22 (brown) in dorsal root ganglion and spinal roots in 20 week fetal spinal cord preparation from rhesus monkey. Image from the standard format of this antibody.

Applications for PMP22 Antibody (Hu1) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50-1:200

Immunohistochemistry-Paraffin

1:50-1:200

Western Blot

reported in scientific literature

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

Tris-Glycine, 0.15 M NaCl

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

0.9 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: PMP22

PMP22 (peripheral myelin protein-22) is an integral membrane glycoprotein of internodal myelin and comprises an estimated 2-5 % of total myelin protein contents of peripheral nervous system. Its functional importance is emphasized by the fact that PMP22 gene mutations are the most common causes for inherited peripheral nerve disorders, also known as CMT (Charcot-Marie-Tooth diseases). Mutations of PMP22 are responsible for more than half of all the patients with inherited peripheral neuropathies, including CMT1A/CMT- type-1A with trisomy of PMP22, hereditary neuropathy with liability to pressure palsies (HNPP) with heterozygous deletion of PMP22, and CMT1E with point mutations of PMP22. These PMP22 associated disorders disrupt the organization of myelin, and subsequently axonal integrity which is untimately responsible for disabilities in patients. While overexpression and point-mutations of the PMP22 gene produces gain-of-function phenotypes, PMP22 deletion results in a loss-of-function phenotype that reveals the normal physiological functions of the PMP22 protein.

Alternate Names

CMT1A, CMT1E, GAS3, GAS-3DSS, growth arrest-specific 3, Growth arrest-specific protein 3, HMSNIA, HNPP, MGC20769, peripheral myelin protein 22, PMP-22, Sp110

Gene Symbol

PMP22

Additional PMP22 Products

Product Documents for PMP22 Antibody (Hu1) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for PMP22 Antibody (Hu1) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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