PMP70 Antibody

Novus Biologicals | Catalog # NBP1-20871

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Cited:

Rat

Predicted:

Mouse (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Flow Cytometry

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
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Product Specifications

Immunogen

Peptide with sequence C-PDGREDQKRKGISD corresponding to internal region according to NP_002849.1.

Epitope

C terminus

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 21248309).

Marker

Proxisomal Membrane Marker

Specificity

This antibody is expected to recognize one isoform (NP_002849.1) only.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for PMP70 Antibody

Immunohistochemistry-Paraffin: PMP70 Antibody [NBP1-20871]

Immunohistochemistry-Paraffin: PMP70 Antibody [NBP1-20871]

Immunohistochemistry-Paraffin: PMP70 Antibody [NBP1-20871] - Staining of Human Testis with antibody at 3.8 ug/mL. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Flow Cytometry: PMP70 Antibody [NBP1-20871]

Flow Cytometry: PMP70 Antibody [NBP1-20871]

Flow Cytometry: PMP70 Antibody [NBP1-20871] - Flow cytometric analysis of paraformaldehyde fixed A431 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.

Applications for PMP70 Antibody

Application
Recommended Usage

Flow Cytometry

10 ug/mL

Immunohistochemistry

2.5 - 3.8 ug/mL

Immunohistochemistry-Paraffin

2.5 - 3.8 ug/mL

Peptide ELISA

Detection limit 1:16000
Application Notes
IHC-P: Human testis shows vesicular staining in Sertoli cells.

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PMP70

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alternate Names

70 kDa peroxisomal membrane protein, ABC43, ATP-binding cassette, sub-family D (ALD), member 3, peroxisomal membrane protein 1 (70kD, Zellweger syndrome), Peroxisomal membrane protein-1 (70kD), PMP70ATP-binding cassette sub-family D member 3, PXMP1dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1)), ZWS2

Entrez Gene IDs

5825 (Human); 19299 (Mouse); 25270 (Rat)

Gene Symbol

ABCD3

UniProt

NP_002849.1 (Human)

Additional PMP70 Products

Product Documents for PMP70 Antibody

Certificate of Analysis

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Product Specific Notices for PMP70 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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