Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Chicken (100%), Porcine (100%). Backed by our 100% Guarantee.

Applications

Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
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Product Specifications

Immunogen

Antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human PNAS4. The immunogen is located within the last 50 amino acids of PNAS4. Amino Acid Squence: VSQELQDELEEAEDAAAS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PPPDE1 Antibody - BSA Free

Western Blot: PPPDE1 AntibodyBSA Free [NBP1-76320]

Western Blot: PPPDE1 AntibodyBSA Free [NBP1-76320]

Western Blot: PPPDE1 Antibody [NBP1-76320] - EL4 cell lysate with PPPDE1 antibody at (A) 1 and (B) 2 ug/ml.

Applications for PPPDE1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PPPDE1

PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4. PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549. PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway. Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with dFdC. At least two isoforms of PNAS4 are known to exist.

Alternate Names

C1orf121, CGI-146, chromosome 1 open reading frame 121, FAM152A, FLJ21998, member A, PNAS-4, PPPDE peptidase domain containing 1, PPPDE peptidase domain-containing protein 1, Protein FAM152A

Gene Symbol

DESI2

UniProt

NP_057160 (Human)

Additional PPPDE1 Products

Product Documents for PPPDE1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for PPPDE1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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