Propranolol hydrochloride
Tocris Bioscience | Catalog # 0624
Key Product Details
Description
Product Description
Propranolol hydrochloride is an β-adrenergic antagonist.
R-enantiomer, S-enantiomer and Glycol Metabolite also available.
Scientific Data Images for Propranolol hydrochloride
Small molecules affect the rate of cardiomyocyte contraction.
Cardiomyocytes were differentiated from the BG01V human embryonic stem cells and assessed for their ability to contract using the Fluo-4 calcium binding assay. Rate interval graph show fluctuations in Fluo-4 fluorescence intensity, indicative of cardiomyocyte contraction, under basal conditions (brown; untreated) and following sequential treatment with Isoproterenol (blue; Catalog # 1747), a beta -adrenergic agonist, and Propranolol (tan; Catalog # 0624), a beta -adrenergic antagonist. Table shows drug concentrations and contraction rate of cardiomyocytes during each treatment. The contraction rate of differentiated cardiomyocytes was determined as the number of contractions (contraction-interval plus relaxation interval) per minute.
Product Specifications for Propranolol hydrochloride
Molecular Weight
Formula
Storage
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.58 | 100 |
Preparing Stock Solutions for Propranolol hydrochloride
The following data is based on the product molecular weight 295.81.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.38 mL | 16.90 mL | 33.81 mL |
| 5 mM | 0.68 mL | 3.38 mL | 6.76 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.38 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 48 publications citing the usage of this product.
- Xie The inhibitory effect of propra. on ATP-sensitive potassium channels in neonatal rat heart. Br.J.Pharmacol. 1998 PMID: 9517376
- Litwin Effects of propra. treatment on left ventricular function and intracellular calcium regulation in rats with postinfarction heart failure. Br.J.Pharmacol. 1999 PMID: 10455325
Product Documents for Propranolol hydrochloride
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Propranolol hydrochloride
For research use only
Citations for Propranolol hydrochloride
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Species: MouseAssay Type: In VivoCell Line/Tissue: heartVerified Customer | Posted 01/05/2018We used Propranolol hydrochroride (cat#0624) to treat postnatal mice to investigate the PI3K activity change
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