Proprotein Convertase 9/PCSK9 Antibody

Novus Biologicals | Catalog # NBP1-51923

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all Proprotein Convertase 9/PCSK9 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-PRYRADEYQPPD corresponding to internal region according to NP_777596.2.

Epitope

C-PRYRADEYQPPD

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Proprotein Convertase 9/PCSK9 Antibody

Western Blot: Proprotein Convertase 9/PCSK9 Antibody [NBP1-51923]

Western Blot: Proprotein Convertase 9/PCSK9 Antibody [NBP1-51923]

Western Blot: Proprotein Convertase 9/PCSK9 Antibody [NBP1-51923] - HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with NBP1-51923 (0.5ug/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with NBP1-51923 (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.

Applications for Proprotein Convertase 9/PCSK9 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.1 - 0.5 ug/ml
Application Notes
WB: In transfected HEK293 transiently expressing full-length human PCSK9 (myc and DYKDDDDK tagged), a doublet of approx. 80-100 kDa band was observed. No bands were observed in mock-transfected HEK293 and the same bands were observed using anti-myc tag antibody.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Proprotein Convertase 9/PCSK9

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Alternate Names

FH3, FHCL3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, PCSK9

Entrez Gene IDs

255738 (Human)

Gene Symbol

PCSK9

UniProt

NP_777596.2 (Human)

Additional Proprotein Convertase 9/PCSK9 Products

Product Documents for Proprotein Convertase 9/PCSK9 Antibody

Certificate of Analysis

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Download SDS

Product Specific Notices for Proprotein Convertase 9/PCSK9 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Obesity
Serine Proteases and Regulators

Citations for Proprotein Convertase 9/PCSK9 Antibody

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