AI-Engineered Designer Proteins

Our AI-Engineered Designer Proteins are engineered across multiple performance dimensions—including stability, efficiency, affinity, and activity—to address key challenges in modern cell culture workflows.

Proteins Designed for Thermal Stability

Engineered for enhanced structural stability, our heat stable proteins maintain high bioactivity in cell culture for longer periods than their wild-type counterparts. This increased stability reduces degradation in media, enabling more consistent results across extended culture durations and minimizing the need for repeated growth factor additions.

Validated with engineered growth factors such as FGF4 Heat Stable protein, which retains biological activity after extended exposure to 37 °C, while wild-type protein rapidly loses function.
 

Heat Stable Proteins

Ideal for cell therapy applications, heat stable proteins ensure:

• Improved Stability: Maintain bioactivity under extended culture and thermal stress conditions
• Consistent Cultures: Reduce variability across long-term experiments and complex cell systems
• Reliable Performance: Deliver reproducible signaling comparable to wild-type proteins
• Workflow Efficiency: Decrease frequency of media supplementation in demanding workflows

Building on enhanced stability, additional engineered proteins further optimize cellular responses through improved activity and receptor engagement.

Proteins Designed for Efficiency

Engineered to be water-soluble and easier to purify, our Wnt/R-Spondin Agonist Proteins effectively activate canonical Wnt signaling.

Wnt/R-Spondin Agonist Proteins

Key reagents for advancing stem cell research, organoid development, and regenerative medicine, these proteins offer:

• All-in-One Activation: Reduce experimental complexity with a single, cost-effective protein
• Streamline Workflows: Save time with a well-defined reagent to substitute for conditioned media or the addition of two individual proteins
• Reliable Performance: Effectively promotes Wnt receptor activation and canonical Wnt signaling
• Increased Solubility: More amenable to media formulations than traditional Wnt proteins

Proteins Designed for Affinity

Engineered to engage target receptors with higher affinity, these proteins show improved binding and cell expansion compared to their standard protein counterparts.

IL-2 (CD122-Directed) Protein

Ideal for large scale CAR T-cell or TIL expansion, this protein ensures:

• Enhanced CD122 Binding: Displays increased affinity to the IL-2 beta receptor (CD122) with decreased affinity to the IL-2 alpha receptor (CD25), resulting in more effective expansion of effector T cells
• Improved Output: Maintains growth of CD8⁺/CD4⁺ T cells for workflows requiring extended T cell proliferation
• Sustained Potential: Improved proliferation capacity and enhanced naive population without increased exhaustion of T cells

Proteins Designed for Hyperactivity

Engineered for enhanced biological activity, hyperactive proteins are designed to deliver stronger cellular responses compared to their wild-type counterparts. By optimizing receptor engagement and signaling efficiency, these proteins enable more effective cell expansion and differentiation in demanding applications.

Examples include IL‑15 Hyperactive protein, engineered for increased affinity to IL‑15 receptors, enabling more efficient expansion of NK cells and tumor-infiltrating lymphocytes (TILs) in cell therapy workflows.

• Enhanced Activity: Achieve higher biological potency compared to wild-type proteins
• Improved Cell Expansion: Support efficient proliferation in demanding cell culture systems
• Optimized Receptor Engagement: Increase signaling efficiency through enhanced affinity
• Greater Workflow Efficiency: Reduce protein usage while maintaining or improving outcomes

Together, these engineered capabilities enable more consistent, efficient, and scalable cell culture workflows.

Featured Content

AI-Engineered Designer Protein Sample Request

We are now offering free samples of our AI-Engineered Designer Proteins. Please fill out the form below and specify which AI-Engineered Designer Proteins you are interested in testing. A team member will reach out to confirm shipping and send you a sample of the designated protein while supplies last. Interested in sampling more than one AI-Engineered Designer Proteins? Let us know in the Comments box.

View All AI-Engineered Designer Proteins

Related Information

• Recombinant Proteins
• Custom Protein Services