PSC 833
Chemical Name: 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A
Purity: ≥98%
Biological Activity
PSC 833 is a P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo.
Song et al.
J.Pharmacol.Exp.Ther., 1998;287:963 -
Complete inhibition of P-glycoprotein by simulataneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody.
Goda et al.
J.Pharmacol.Exp.Ther., 2007;320:81 -
Quantitation of doxorubicine uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells.
Shen et al.
J.Pharmacol.Exp.Ther., 2008;324:95 -
Dynamic assessment of mitoxan. resistance and modulation of multidrug resistance by Valspodar (PSC833) in multidrug resistance human cancer cells.
Shen et al.
J.Pharmacol.Exp.Ther., 2009;330:423
Product Datasheets
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Citations for PSC 833
The citations listed below are publications that use Tocris products. Selected citations for PSC 833 include:
5 Citations: Showing 1 - 5
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A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier.
Authors: Kim and Bynoe
J Clin Invest 2016;126:1717
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Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism.
Authors: Slosky Et al.
Mol Pharmacol 2013;84:774
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Ciprofloxacin is actively transported across bronchial lung epithelial cells using a Calu-3 air interface cell model.
Authors: Ong Et al.
Antimicrob Agents Chemother 2013;57:2535
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Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17β-OE involves differential regulation of plasma membrane associated estrogen receptors.
Authors: Elbaradie Et al.
Sci Rep 2013;1833:1165
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Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells.
Authors: Lipka Et al.
PLoS One 2012;7:e40853
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50 mg/kg of PSC833 for 15 minutes
