PSC 833

Catalog # Availability Size / Price Qty
4042/1
PSC 833 | CAS No. 121584-18-7 | Multidrug Transporter Inhibitors
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Description: Inhibitor of P-gp-mediated MDR
Alternative Names: Valspodar

Chemical Name: 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A

Purity: ≥98%

Product Details
Citations (5)
Reviews

Biological Activity

P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

Technical Data

M.Wt:
1214.62
Formula:
C63H111N11O12
Solubility:
Soluble to 4 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
121584-18-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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