PSC 833

  ( 4 citations )    
Product Datasheet
Catalog Number:4042
Alternate Names:Valspodar
Chemical Name:6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A
Product Details
Citations (4)
Reviews
Biological Activity
P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).
Technical Data
  • M.Wt:
    1214.62
  • Formula:
    C63H111N11O12
  • Solubility:
    Soluble to 4 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    121584-18-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PSC 833 include:

4 Citations: Showing 1 - 4
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  1. A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier.
    Authors: Kim and Bynoe
    J Clin Invest  2016;126:1717
  2. Ciprofloxacin is actively transported across bronchial lung epithelial cells using a Calu-3 air interface cell model.
    Authors: Ong Et al.
    Antimicrob Agents Chemother  2013;57:2535
  3. Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17β-estradiol involves differential regulation of plasma membrane associated estrogen receptors.
    Authors: Elbaradie Et al.
    Sci Rep  2013;1833:1165
  4. Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells.
    Authors: Lipka Et al.
    PLoS One  2012;7:e40853

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