PSC 833

Tocris Bioscience | Catalog # 4042

Inhibitor of P-gp-mediated MDR
Tocris Bioscience

Key Product Details

Description

Inhibitor of P-gp-mediated MDR

Alternative Names

Valspodar
View all Multidrug Transporter Inhibitors »

Product Description

PSC 833 is a P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

Product Specifications for PSC 833

Molecular Weight

1214.62

Formula

C63H111N11O12

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A

CAS Number

121584-18-7

PubChem ID

5281884

InChI Key

YJDYDFNKCBANTM-QCWCSKBGSA-N

SMILES

C[C@H](C)[C@@H](C1=O)NC([C@H](CC(C)C)N(C(CN(C([C@H]([C@H](C)C)NC([C@H]([C@]([C@H](C)C/C=C/C)=O)N(C([C@H]([C@@H](C)C)N(C([C@H](CC(C)C)N(C([C@H](CC(C)C)N(C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N1C)=O)=O)=O)C)=O)C)=O)C)=O)C)=O)=O)C)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2 2

Preparing Stock Solutions for PSC 833

The following data is based on the product molecular weight 1214.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.02 mM 41.17 mL 205.83 mL 411.65 mL
0.1 mM 8.23 mL 41.17 mL 82.33 mL
0.2 mM 4.12 mL 20.58 mL 41.17 mL
1 mM 0.82 mL 4.12 mL 8.23 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

Product Documents for PSC 833

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PSC 833

For research use only

Customer Reviews for PSC 833 (1)

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  • Highly stable
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human brain endothelial cell
    Verified Customer | Posted 05/09/2020
    50 mg/kg of PSC833 for 15 minutes
    PSC 833 4042

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