PT-65

Tocris Bioscience | Catalog # 7651

Potent GSK3 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent GSK3 Degrader (PROTAC®)
View all Active Degraders »

Product Description

PT-65 is a potent GSK3 Degrader (PROTAC®) (DC50 = 28.3 nM and 34.2 nM against GSK3α and GSK3β, respectively, in SH-SY5Y cells). It suppresses Okadaic acid (Cat. No. 1136) -induced tau hyperphosphorylation and ameliorates learning and memory impairments in rat models of Alzheimer's disease.

GSK3β antibodies validated for Western Blot also available: Catalog # NBP1-47470 and AF2157.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for PT-65

Molecular Weight

1082.19

Formula

C51H63N13O12S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-Amino-6-(4-((4-(4-(1-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-1H-1,2,3-triazol-4-yl)butyl)piperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide

CAS Number

2721998-87-2

InChI Key

QJSFLEBIQZMJQF-UHFFFAOYSA-N

SMILES

O=C(NC=1C=NC=CC1)C=2N=C(C=NC2N)C3=CC=C(C=C3)S(=O)(=O)N4CCN(CC4)CCCCC=5N=NN(C5)CCOCCOCCOCCOCCOCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 108.22 100

Preparing Stock Solutions for PT-65

The following data is based on the product molecular weight 1082.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.92 mL 4.62 mL 9.24 mL
5 mM 0.18 mL 0.92 mL 1.85 mL
10 mM 0.09 mL 0.46 mL 0.92 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PT-65

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PT-65

For research use only

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