GH (Growth Hormone; Somatotropin) is a polypeptide hormone that regulates somatic growth and metabolism through interactions with Growth Hormone R/GHR. GH is released from the anterior pituitary in response to GH-releasing Hormone (GHRH) and Ghrelin, while its secretion is suppressed by Somatostatin. GH levels may also be regulated by Thyrotropin-releasing Hormone, Leptin, Galanin, Neuropeptide Y, and Cortisol. GH can circulate in complex with a shed soluble form of GHR known as GHBP. In addition to promoting bone and muscle mass, GH exerts immunomodulatory effects and induces lipolysis, lactation, amino acid uptake, and protein synthesis. Overproduction of GH can lead to acromegaly, a disorder characterized by enlargement of the hands, feet, and facial features, as well as enhanced risk of cardiovascular disease, respiratory disease, and malignancy. GH deficiency in adults may lead to increases in cardiovascular risk, body fat, and insulin sensitivity, as well as decreased muscle mass and bone density.
Quantikine Immunoassay Control Set 1076 Human Growth Hormone
R&D Systems | Catalog # QC99
Key Product Details
Species
Applications
Product Summary for Quantikine Immunoassay Control Set 1076 Human Growth Hormone
INTENDED USE & DESCRIPTION
For use as quantitative controls for the determination of cytokine concentrations in biological fluids. Concentrations have been assigned using R&D Systems’ Quantikine® kits. Controls are prepared in a buffered protein solution with preservatives. They contain recombinant human cytokines at low, medium and high concentrations. Controls are supplied lyophilized.
STORAGE & STABILITY
Unreconstituted Controls should be stored at 2-8 °C and are stable for at least 6 months from date of receipt. Depending on the analyte of interest, reconstituted controls may be stable when stored at < -20 °C. Users should evaluate the frozen stability of the controls in their application or discard after use.
REAGENT PREPARATION
Reconstitute each vial with the volume of deionized or distilled water indicated on the product datasheet.
PROCEDURE & EXPECTED VALUES
Controls should be assayed in the same manner as unknown specimens.
The acceptable ranges for the analytes in these controls are printed on the product datasheet. Due to possible variations in techniques and methodologies, it is recommended that each laboratory determine its own target range. Laboratories using other test systems should establish their own acceptable ranges as these assays may produce different values.
TECHNICAL HINTS & LIMITATIONS OF THE PROCEDURE
• The ranges were determined using R&D Systems’ Quantikine kits. If expected values are not obtained, verify that the lot numbers on the vials correspond with the lot numbers listed above and the correct volume of deionized or distilled water was used for reconstitution of the controls.
• The results obtained with these controls depend upon several factors associated with methods and instrumentation. Test systems other than those supplied by R&D Systems may result in values that differ from those printed on this product datasheet.
Formulation, Preparation, and Storage
Shipping
Storage
Background: Growth Hormone
Alternate Names
Entrez Gene IDs
Gene Symbol
Additional Growth Hormone Products
Product Documents for Quantikine Immunoassay Control Set 1076 Human Growth Hormone
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Quantikine Immunoassay Control Set 1076 Human Growth Hormone
For research use only
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