Protein/Peptide Hormones and Regulators

Protein/peptide hormones are typically generated as pro-hormones that are secreted into the circulatory system following specific stimuli, and exert their effects in an endocrine manner. These hormones generally act through receptors on the plasma membrane which activate second messenger protein cascades and impact a myriad of biological processes. R&D Systems offers a wide range of related products which are involved in glucose homeostasis (glucagon, insulin), the growth hormone (GH)/insulin-like growth factor (IGF) pathway, erythropoiesis (erythropoietin), vasoconstriction (endothelin), pain signaling (substance P), reproduction (follicle stimulating hormone (FSH, relaxin, prolactin), and more.

Vasoactive Peptide Hormones and Regulators

Endothelin Family
ECE-1ECE-2EDNRA/Endothelin R Type AEDNRB/Endothelin R Type BEndothelin-1
Endothelin-2Endothelin-3Endothelin ETA Receptor AntagonistsEndothelin ETB Receptor AgonistsEndothelin ETB Receptor Antagonists
Non-selective Endothelin Receptor AgonistsNon-selective Endothelin Receptor Antagonists   
Renin-Angiotensin System
ACE/CD143ACE InhibitorsACE SubstratesACE-2AGTR-1
AGTR-2AGTR1bAminopeptidase A/ENPEPAminopeptidase B/RNPEPAminopeptidase Inhibitors
Aminopeptidase N/CD13Aminopeptidase O/ONPEPAngiopoietin-like Protein 4/ANGPTL4Angiotensin AT1 Receptor AntagonistsAngiotensin AT2 Receptor Antagonists
Non-selective Angiotensin AT Receptor AgonistsAdditional Angiotensin AT2 Receptor PeptidesOther Angiotensin ReceptorsCathepsin A/Lysosomal Carboxypeptidase AChymase/CMA1
CorinFrizzled-8GPER/GPR30Kallikrein 1Kallikrein 2
MasMegalin/LRP2Mineralocorticoid R/NR3C2Mineralocorticoid Receptor AgonistsMineralocorticoid Receptor Antagonists
MRGPRDNeprilysin/CD10NeurolysinProlyl Oligopeptidase/PREPPSGR
ReninRenin RSerpin A8/AngiotensinogenSLC13A3/NaDC3Thimet Oligopeptidase/THOP1
Other Vasoactive Hormones and Modulators
Adrenomedullin/ADMAdrenomedullin R/ADMRAdropinApelinApelin Receptor Agonists
Apelin Receptor AntagonistsAPJAtrial Natriuretic Peptide/ANPBNPBradykinin RB1/BDKRB1
Bradykinin RB2/BDKRB2Bradykinin Receptor AgonistsBradykinin Receptor AntagonistsCalcitonin and Related Receptor AgonistsCalcitonin and Related Receptor Antagonists
Calcitonin RCNPCopeptinCorinCRLR
Insulysin/IDELeucyl-cystinyl Aminopeptidase/LNPEPNeprilysin/CD10Neurophysin IINPRA/NPR1
NPRB/NPR2NPRC/NPR3OXTROxytocinOxytocin Receptor Agonists
Oxytocin Receptor AntagonistsRAMP1RAMP2RAMP3Urotensin-II R
V1b Vasopressin R/AVPR1BV2 Vasopressin R/AVPR2Arg8-VasopressinV1a Vasopressin R/AVPR1AVIP
VIPR1/VPAC1VIPR2