IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
Quantikine Immunoassay Control Set 1156, Human Total IL-18
R&D Systems | Catalog # QC231
For use with catalog number DL180
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Key Product Details
Species
Human
Applications
Control
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Formulation, Preparation, and Storage
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: IL-18/IL-1F4
Long Name
Interleukin 18
Alternate Names
IGIF, IL-1F4, IL-1g, IL18
Gene Symbol
IL18
Additional IL-18/IL-1F4 Products
Product Documents for Quantikine Immunoassay Control Set 1156, Human Total IL-18
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Quantikine Immunoassay Control Set 1156, Human Total IL-18
For research use only
Customer Reviews for Quantikine Immunoassay Control Set 1156, Human Total IL-18 (2)
5 out of 5
2 Customer Ratings
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Verified Customer | Posted 01/27/2021Great QC results well within range. Med QC is in well B3 and B4, High QC is in H11 and H12
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Verified Customer | Posted 01/27/2021QC ran for IL-18 assay RnD Medium in wells A3 and A4 RnD High in wells H11, H12 Picture of the plate before adding the stop solution
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