Chemical Name: N-(4-Bromophenyl)-4-phenyl-2-thiazolamine
Biological Activitygp130 modulator. Binds gp130, promotes Myc expression, increases lactate production and activates downstream JAK/STAT signaling pathways in hair follicle stem cells. Also increases articular chondrocyte activation and facilitates joint repair by regulating cartilage growth and differentiation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity.
Alam et al.
ACS Chem.Neurosci., 2018;9:462
Lactate dehydrogenase activity drives hair follicle stem cell activation.
Flores et al.
Nat.Cell Biol., 2017;19:1017
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