Recombinant Human BTN2A1/Butyrophilin 2A1 Protein, CF
Recombinant Human BTN2A1/Butyrophilin 2A1 Protein, CF Summary
Gln29-Ala248, with a C-terminal 6-His tag
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 100 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
When Recombinant Human BTN2A1/Butyrophilin 2A1 (Catalog # 9058-BT) is coated at 1 µg/mL, Recombinant Human DC-SIGN/CD209 Fc Chimera (Catalog # 161-DC) binds with a ED50 of
Butyrophilin 2A1 (BTN2A1) is an approximately 70 kDa widely expressed and variably glycosylated type I transmembrane glycoprotein (1). Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 258 aa cytoplasmic domain (2). Alternative splicing generates additional isoforms of human Butyrophilin 2A1 that lack the first Ig-like domain or transmembrane segment as well as isoforms with substitutions and deletions in the cytoplasmic region. BTN2A1 is widely expressed including on colonic epithelial cells, on immune cells, and in milk fat globules (3, 4). It binds to the C-type lectin DC-SIGN on monocyte-derived dendritic cells, and this interaction can be blocked by soluble gp130 from HIV (3). The polymorphism of BTN2A1 has been associated with metabolic syndrome, type II diabetes mellitus, chronic kidney disease, and hypertension (5, 6).
- Arnett, H.A. and J.L. Viney (2014) Nat. Rev. Immunol. 14:559.
- Tazi-Ahnini, R. et al. (1997) Immunogenetics 47:55.
- Malcherek, G. et al. (2007) J. Immunol. 179:3804.
- Cavaletto, M. et al. (2002) Proteomics 2:850.
- Oguri, M. et al.(2011) J. Med. Genet. 48:787.
- Horibe, H. et al. (2014) Mol. Med. Rep. 9:808.
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