Recombinant Human CD79A Protein, CF
Recombinant Human CD79A Protein, CF Summary
Leu33-Arg143, with a C-terminal 6-His tag
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS and EDTA.|
|Reconstitution||Reconstitute at 250 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
2 μg/lane of Recombinant Human CD79A was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® blue staining, showing bands at 38 - 43 kDa.
CD79A (also known as Mb-1, Ig alpha and B cell antigen receptor complex-associated protein alpha-chain) is a 30-40 kDa member of the Ig-Superfamily. It is expressed on B cells, and forms a covalent heterodimer with CD79B. Heterodimers of CD79A and CD79B interacts noncovalently with membrane Ig, forming the B cell antigen receptor (BCR) (1). Within this complex, membrane Ig detects antigen while CD79AB initiates signaling (1). CD79A is essential for the differentiation of pre-B cells, and the pre-BCR regulates the surface expression of IL-7R (2). Mature human CD79A is a type I transmembrane glycoprotein. It contains an extracellular region (aa 33-143) with one C2-type Ig-like domain (aa 33-116), and an ITAM-containing cytoplasmic domain (aa 177-205) (3). Within the ECD, human CD79A shares 57% amino acid sequence identity with mouse and rat CD79A.
- Tseng, J. et al. (1997) Blood, 89:1513.
- Kurosaki, T. (2000) Current opinion in immunology, 12:276.
- Radaev, Sergei et al. (2010) Structure 18:934.
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