Recombinant Human FPRP/PTGFRN Fc Chimera Protein, CF

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Recombinant Human FPRP/PTGFRN Fc Chimera Protein SDS-PAGE
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Product Details

Recombinant Human FPRP/PTGFRN Fc Chimera Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. When Recombinant Human FPRP/PTGFRN Fc Chimera (Catalog # 10433-FP) is immobilized at 5 µg/mL (100 µL/well), Biotinylated Recombinant Human CD9 Fc Chimera binds with an ED50 of 3-18 μg/mL.
Human embryonic kidney cell, HEK293-derived human FPRP/PTGFRN protein
Accession # Q9P2B2.2
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
117 kDa
120-140 kDa, under reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

SDS-PAGE Recombinant Human FPRP/PTGFRN Fc Chimera Protein SDS-PAGE View Larger

2 μg/lane of Recombinant Human FPRP/PTGFRN Fc Chimera Protein (Catalog # 10433-FP) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 120-140 kDa and 240-280 kDa, respectively.

Reconstitution Calculator

Reconstitution Calculator

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Background: FPRP/PTGFRN

Prostoglandin F2 receptor negative regulator (PTGFRN), also known as CD9P-1, EWI-F, and CD315, is an integral type I transmembrane glycoprotein expressed on subsets of cells in ovary, uterus, lung, and heart (1-4). PTGFRN is a member of the Glu-Trp-Ile (EWI) subfamily within the Ig superfamily of molecules. The extracellular domain (ECD) of mature human PTGFRN contains six Ig-like C2-type domains and an EWI motif that acts as binding sites for actin-linking ezrin-radixin-moesin (ERM) proteins (1). The ECD of human PTGFRN shares 90% and 89% amino acid identity with mouse and rat PTGFRN, respectively. PTGFRN forms complexes with tetraspanins CD9 and CD81, linking these molecules to the intracellular actin cytoskeleton and regulating cell motility and polarity (1, 2). Increased expression of CD9 and CD81 inhibits the HEK/PTGFRN cell motility on collagen-I (3). In addition, PTGFRN expression positively correlates with the metastatic status of hLT and the upregulation of PTGFRN expression could be a mechanism involved in the loss of CD9 in solid tumors, such as in lung cancer (4)

  1. Sala-Valdes, M. et al. (2006) J Biol Chem. 281:19665.
  2. Stipp, C. S. et al. (2001) J Biol Chem. 276:4853.
  3. Chambrion, C. et al. (2010) PLoS One. 5:11219.
  4. Guilmain, W. et al. (2011) Br. J Cancer. 104:496.
Long Name
Prostaglandin F2-alpha Receptor Regulatory Protein
Entrez Gene IDs
5738 (Human); 19221 (Mouse); 29602 (Rat)
Alternate Names


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