Recombinant Human FPRP/PTGFRN Fc Chimera Protein, CF Summary
|Human FPRP/PTGFRN |
Accession # Q9P2B2.2
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CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
2 μg/lane of Recombinant Human FPRP/PTGFRN Fc Chimera Protein (Catalog # 10433-FP) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 120-140 kDa and 240-280 kDa, respectively.
Prostoglandin F2 receptor negative regulator (PTGFRN), also known as CD9P-1, EWI-F, and CD315, is an integral type I transmembrane glycoprotein expressed on subsets of cells in ovary, uterus, lung, and heart (1-4). PTGFRN is a member of the Glu-Trp-Ile (EWI) subfamily within the Ig superfamily of molecules. The extracellular domain (ECD) of mature human PTGFRN contains six Ig-like C2-type domains and an EWI motif that acts as binding sites for actin-linking ezrin-radixin-moesin (ERM) proteins (1). The ECD of human PTGFRN shares 90% and 89% amino acid identity with mouse and rat PTGFRN, respectively. PTGFRN forms complexes with tetraspanins CD9 and CD81, linking these molecules to the intracellular actin cytoskeleton and regulating cell motility and polarity (1, 2). Increased expression of CD9 and CD81 inhibits the HEK/PTGFRN cell motility on collagen-I (3). In addition, PTGFRN expression positively correlates with the metastatic status of hLT and the upregulation of PTGFRN expression could be a mechanism involved in the loss of CD9 in solid tumors, such as in lung cancer (4)
- Sala-Valdes, M. et al. (2006) J Biol Chem. 281:19665.
- Stipp, C. S. et al. (2001) J Biol Chem. 276:4853.
- Chambrion, C. et al. (2010) PLoS One. 5:11219.
- Guilmain, W. et al. (2011) Br. J Cancer. 104:496.
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