Recombinant Human IL-15 Protein

GMP Version Available: 247-GMP
GMP

Carrier Free

Catalog # Availability Size / Price Qty
247-ILB-005/CF
247-ILB-025/CF
247-ILB-500/CF

With Carrier

Catalog # Availability Size / Price Qty
247-ILB-005
247-ILB-025
Recombinant Human IL-15 Protein Bioactivity
2 Images
Product Details
Citations (138)
FAQs
Reviews (3)

Recombinant Human IL-15 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE with silver staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is 0.3-2.6 ng/mL.
The specific activity of Recombinant Human IL-15 is approximately 4.5 x 105 U/μg, which is calibrated against recombinant human IL-15 WHO International Standard (NIBSC code: 95/554).   Specific activity is for reference purposes only and is not routinely tested.  
Source
E. coli-derived human IL-15 protein
Asn49-Ser162
Accession #
N-terminal Sequence
Analysis
Asn49
Predicted Molecular Mass
13 kDa
SDS-PAGE
10 kDa, reducing conditions

Product Datasheets

247-ILB (with carrier)

247-ILB/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

247-ILB

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

247-ILB/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Bioactivity Recombinant Human IL-15 Protein Bioactivity View Larger

Recombinant Human IL-15 (Catalog # 247-ILB) stimulates cell proliferation in the MO7e human megakaryocytic leukemic cell line. The ED50 for this effect is 0.3-2.6 ng/mL.

SDS-PAGE Recombinant Human IL-15 Protein SDS-PAGE View Larger

1 µg/lane of Recombinant Human IL-15 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a major band at 10 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-15

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 and plays an important role in many immunological diseases (1, 2). Mature human IL-15 protein shares 70% amino acid sequence identity with mouse and rat IL-15. Alternative splicing generates isoforms of Interleukin 15 with either a long or short signal peptide (LSP or SSP), and the SSP isoform is retained intracellularly (3). The IL-15 protein binds with high affinity to IL-15 R alpha (4). It binds with lower affinity to a complex of IL-2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL-2 receptor complex (5). IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface (6). The dominant mechanism of IL-15 action is known as transpresentation in which IL-15 and IL-15 R alpha are coordinately expressed on the surface of one cell and interact with complexes of IL-2 R beta / gamma c on adjacent cells (7). This enables cells to respond to Interleukin 15 even if they do not express IL-15 R alpha (6). In human and mouse, soluble IL-15-binding forms of IL-15 R alpha can be generated by proteolytic shedding and bind up nearly all the IL-15 protein in circulation (8-10). Soluble IL-15 R alpha functions as an inhibitor that limits IL-15 action (4, 9). Ligation of membrane-associated IL-15/IL-15 R alpha complexes also induces reverse signaling that promotes activation of the IL-15/IL-15 R alpha expressing cells (11). IL-15 induces or enhances the differentiation, maintenance, or activation of multiple T cell subsets including NK, NKT, Th17, Treg, and CD8+ memory cells (12-16). An important component of these functions is the ability of IL-15 to induce dendritic cell differentiation and inflammatory activation (11, 14). IL-15 exhibits anti-tumor activity independent of its actions on NK cells or CD8+ T cells (17). It also inhibits the deposition of lipid in adipocytes, and its circulating levels are decreased in obesity (18).

References
  1. De Sabatino, A. et al. (2011) Cytokine Growth Factor Rev. 22:19.
  2. Grabstein, K. et al. (1994) Science 264:965.
  3. Tagaya, Y. et al. (1997) Proc. Natl. Acad. Sci. USA 94:14444.
  4. Giri, J.G. et al. (1995) EMBO J. 14:3654.
  5. Giri, J. et al. (1994) EMBO J. 13:2822.
  6. Dubois, S. et al. (2002) Immunity 17:537.
  7. Castillo, E.F. and K.S. Schluns (2012) Cytokine 59:479.
  8. Budagian, V. et al. (2004) J. Biol. Chem. 279:40368.
  9. Mortier, E. et al. (2004) J. Immunol. 173:1681.
  10. Bergamaschi, C. et al. (2012) Blood 120:e1.
  11. Budagian, V. et al. (2004) J. Biol. Chem. 279:42192.
  12. Mortier, E. et al. (2003) J. Exp. Med. 205:1213.
  13. Gordy, L.E. et al. (2011) J. Immunol. 187:6335.
  14. Harris, K.M. (2011) J. Leukoc. Biol. 90:727.
  15. Xia, J. et al. (2010) Clin. Immunol. 134:130.
  16. Schluns, K.S. et al. (2002) J. Immunol. 168:4827.
  17. Davies, E. et al. (2010) J. Leukoc. Biol. 88:529.
  18. Barra, N.G. et al. (2010) Obesity 18:1601.
Long Name
Interleukin 15
Entrez Gene IDs
3600 (Human); 16168 (Mouse); 25670 (Rat); 102119613 (Cynomolgus Monkey); 493682 (Feline)
Alternate Names
IL15; IL-15; IL-15MGC9721; interleukin 15; interleukin-15

Citations for Recombinant Human IL-15 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

138 Citations: Showing 1 - 10
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  1. Correction of murine sickle cell disease by allogeneic haematopoietic cell transplantation with anti-3rd party veto cells
    Authors: AK Singh, E Schetzen, SK Yadav, EB Lustig, WH Liu, RK Yadav, RP Gale, K McGinnis, Y Reisner
    Bone marrow transplantation, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Epstein-Barr virus peptides derived from latent cycle proteins alter NKG2A?+?NK cell effector function
    Authors: B Mbiribindi, JK Pena, MP Arvedson, C Moreno Rom, SR McCarthy, OL Hatton, CO Esquivel, OM Martinez, SM Krams
    Sci Rep, 2020;10(1):19973.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. MHC Class I-Restricted TCR-Transgenic CD4+ T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo
    Authors: SJ Schober, M Thiede, H Gassmann, C Prexler, B Xue, D Schirmer, D Wohlleber, S Stein, TGP Grünewald, DH Busch, GHS Richter, SEG Burdach, U Thiel
    Cells, 2020;9(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  4. Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
    Authors: JB McBrien, M Mavigner, L Franchitti, SA Smith, E White, GK Tharp, H Walum, K Busman-Suh, CR Aguilera-S, WO Thayer, RA Spagnuolo, M Kovarova, A Wahl, B Cervasi, DM Margolis, TH Vanderford, DG Carnathan, M Paiardini, JD Lifson, JH Lee, JT Safrit, SE Bosinger, JD Estes, CA Derdeyn, JV Garcia, DA Kulpa, A Chahroudi, G Silvestri
    Nature, 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  5. Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence
    Authors: L Swadling, LJ Pallett, MO Diniz, JM Baker, OE Amin, KA Stegmann, AR Burton, NM Schmidt, A Jeffery-Sm, N Zakeri, K Suveizdyte, F Froghi, G Fusai, WM Rosenberg, BR Davidson, A Schurich, AK Simon, MK Maini
    Cell Rep, 2020;30(3):687-698.e6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  6. Developmental plasticity allows outside-in immune responses by resident memory T cells
    Authors: R Fonseca, LK Beura, CF Quarnstrom, HE Ghoneim, Y Fan, CC Zebley, MC Scott, NJ Fares-Fred, S Wijeyesing, EA Thompson, H Borges da, V Vezys, B Youngblood, D Masopust
    Nat. Immunol., 2020;0(0):.
    Species: CD45.1 P14TCM
    Sample Types: Whole Cells
    Applications: Cell Culture
  7. Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia
    Authors: N Gimenez, R Tripathi, A Giró, L Rosich, M López-Guer, I López-Orej, H Playa-Albi, F Arenas, JM Mas, P Pérez-Galá, J Delgado, E Campo, J Farrés, D Colomer
    Scientific Reports, 2020;10(1):22153.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  8. "Inflammescent" CX3CR1+CD57+ CD8 T cells are generated and expanded by IL-15
    Authors: SR Morris, B Chen, JC Mudd, S Panigrahi, CL Shive, SF Sieg, CM Cameron, DA Zidar, NT Funderburg, SA Younes, B Rodriguez, S Gianella, MM Lederman, ML Freeman
    JCI Insight, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. The DARC-null trait is associated with moderate modulation of NK cell profiles and unaltered cytolytic T cell profiles in black South Africans
    Authors: KK Naidoo, ZB Shangase, T Rashid, A Ngubane, N Ismail, T Ndung'u, CF Thobakgale
    PLoS ONE, 2020;15(11):e0242448.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Increased IL-2 and Reduced TGF-&beta Upon T-Cell Stimulation are Associated with GM-CSF Upregulation in Multiple Immune Cell Types in Multiple Sclerosis
    Authors: J Aram, N Frakich, E Morandi, M Alrouji, A Samaraweer, D Onion, I Spendlove, SL Colombo, R Tanasescu, B Gran, CS Constantin
    Biomedicines, 2020;8(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  11. Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells
    Authors: M López-Guer, S Xargay-Tor, P Fuentes, J Roldán, B González-F, L Rosich, E Silkensted, MJ García-Leó, E Lee-Vergés, N Giménez, A Giró, M Aymerich, N Villamor, J Delgado, A López-Guil, XS Puente, E Campo, ML Toribio, D Colomer
    Oncogene, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
    Authors: K Renner, C Bruss, A Schnell, G Koehl, HM Becker, M Fante, AN Menevse, N Kauer, R Blazquez, L Hacker, SM Decking, T Bohn, S Faerber, K Evert, L Aigle, S Amslinger, M Landa, O Krijgsman, EA Rozeman, C Brummer, PJ Siska, K Singer, S Pektor, M Miederer, K Peter, E Gottfried, W Herr, I Marchiq, J Pouyssegur, WR Roush, S Ong, S Warren, T Pukrop, P Beckhove, SA Lang, T Bopp, CU Blank, JL Cleveland, PJ Oefner, K Dettmer, M Selby, M Kreutz
    Cell Rep, 2019;29(1):135-150.e9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells
    Authors: C Solà-Riera, S Gupta, HG Ljunggren, J Klingström
    Sci Rep, 2019;9(1):834.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice
    Authors: JD Ventura, J Beloor, E Allen, T Zhang, KA Haugh, PD Uchil, C Ochsenbaue, C Kieffer, P Kumar, TJ Hope, W Mothes
    PLoS Pathog., 2019;15(12):e1008161.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  15. KLF12 Regulates Mouse NK Cell Proliferation
    Authors: VC Lam, L Folkersen, OA Aguilar, LL Lanier
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency
    Authors: DN Nguyen, TL Roth, PJ Li, PA Chen, R Apathy, MR Mamedov, LT Vo, VR Tobin, D Goodman, E Shifrut, JA Bluestone, JM Puck, FC Szoka, A Marson
    Nat. Biotechnol., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  17. Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II?induced arthritis
    Authors: ZY Li, JJ Zhou, CL Luo, LM Zhang
    Mol Med Rep, 2019;20(5):4540-4550.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival
    Authors: A Gras Navar, H Espedal, JV Joseph, L Trachsel-M, M Bahador, B Tore Gjert, E Klæboe Kri, A Simonsen, H Miletic, P Øyvind Eng, MA Rahman, M Chekenya
    Cancers (Basel), 2019;11(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Microenvironmental IL1beta promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
    Authors: R Eyre, DG Alférez, A Santiago-G, K Spence, JC McConnell, C Hart, BM Simões, D Lefley, C Tulotta, J Storer, A Gurney, N Clarke, M Brown, SJ Howell, AH Sims, G Farnie, PD Ottewell, RB Clarke
    Nat Commun, 2019;10(1):5016.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  20. Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies
    Authors: HJ Yoo, Y Liu, L Wang, ML Schubert, JM Hoffmann, S Wang, B Neuber, A Hückelhove, U Gern, A Schmitt, C Müller-Tid, P Dreger, A Mokhir, M Schmitt, L Sellner
    Int J Mol Sci, 2019;20(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: CAR-T (Bioassay)
  21. Immunogenic neoantigens derived from gene fusions stimulate T cell responses
    Authors: W Yang, KW Lee, RM Srivastava, F Kuo, C Krishna, D Chowell, V Makarov, D Hoen, MG Dalin, L Wexler, R Ghossein, N Katabi, Z Nadeem, MA Cohen, SK Tian, N Robine, K Arora, H Geiger, P Agius, N Bouvier, K Huberman, K Vanness, JJ Havel, JS Sims, RM Samstein, R Mandal, J Tepe, I Ganly, AL Ho, N Riaz, RJ Wong, N Shukla, TA Chan, LGT Morris
    Nat. Med., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo
    Authors: C Schleiss, W Ilias, O Tahar, Y Güler, L Miguet, C Mayeur-Rou, L Mauvieux, LM Fornecker, E Toussaint, R Herbrecht, F Bertrand, M Maumy-Bert, T Martin, S Fournel, P Georgel, S Bahram, L Vallat
    Sci Rep, 2019;9(1):701.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. In�Vitro Expansion of Anti-viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells
    Authors: K Kuranda, S Caillat-Zu, S You, R Mallone
    Mol Ther Methods Clin Dev, 2019;13(0):112-120.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals
    Authors: ER Wonderlich, K Subramania, B Cox, A Wiegand, C Lackman-Sm, MJ Bale, M Stone, R Hoh, MF Kearney, F Maldarelli, SG Deeks, MP Busch, RG Ptak, DA Kulpa
    PLoS Pathog., 2019;15(10):e1008074.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. In vitro and in vivo characterization of an interleukin-15 antagonist peptide by metabolic stability, 99m Tc-labeling, and biological activity assays
    Authors: Y Rodríguez-, A Cabrales-R, A Perera-Pin, A Prats-Capo, HE Garay-Pére, O Reyes-Acos, E Pérez-Garc, A Chico-Capo, A Santos-Sav
    J. Pept. Sci., 2018;24(4):e3078.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae
    Authors: EW Kim, RMB Teles, S Haile, PT Liu, RL Modlin
    PLoS Negl Trop Dis, 2018;12(7):e0006608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-?
    Authors: T Oth, THPM Habets, WTV Germeraad, MI Zonneveld, GMJ Bos, J Vanderloch
    BMC Immunol., 2018;19(1):8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Interferon-? converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1
    Authors: R Liu, J Merola, TD Manes, L Qin, GT Tietjen, F López-Girá, V Broecker, C Fang, C Xie, PM Chen, NC Kirkiles-S, D Jane-Wit, JS Pober
    JCI Insight, 2018;3(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Distinct human circulating NKp30+Fc?RI?+CD8+ T cell population exhibiting high natural killer-like antitumor potential
    Authors: MP Correia, A Stojanovic, K Bauer, D Juraeva, LO Tykocinski, HM Lorenz, B Brors, A Cerwenka
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  30. Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect
    Authors: M Felices, AJ Lenvik, R McElmurry, S Chu, P Hinderlie, L Bendzick, MA Geller, J Tolar, BR Blazar, JS Miller
    JCI Insight, 2018;3(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking
    Authors: AH Turaj, KL Cox, CA Penfold, RR French, CI Mockridge, JE Willoughby, AL Tutt, J Griffiths, PWM Johnson, MJ Glennie, R Levy, MS Cragg, SH Lim
    Sci Rep, 2018;8(1):2278.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition
    Authors: SR Kim, JM Lewis, BM Cyrenne, PF Monico, FN Mirza, KR Carlson, FM Foss, M Girardi
    Oncotarget, 2018;9(49):29193-29207.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling
    Authors: X Zhao, S Sankaran, J Yap, CT Too, ZZ Ho, G Dolton, M Legut, EC Ren, AK Sewell, A Bertoletti, PA MacAry, J Brzostek, NRJ Gascoigne
    Nat Commun, 2018;9(1):2716.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation
    Authors: M Najar, M Fayyad-Kaz, N Meuleman, D Bron, H Fayyad-Kaz, L Lagneaux
    J Cell Commun Signal, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Inhibition of IL-10 and TGF-? receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells
    Authors: C Thepmalee, A Panya, M Junking, T Chieochans, PT Yenchitsom
    Hum Vaccin Immunother, 2018;0(0):0.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment
    Authors: L Golden-Mas, RH McMahan, MS Kriss, AL Kilgore, L Cheng, RJ Dran, A Wieland, HR Rosen
    Hepatol Commun, 2018;2(4):364-375.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. IL-15 super-agonist (ALT-803) enhances natural killer (NK) cell function against ovarian cancer
    Authors: M Felices, S Chu, B Kodal, L Bendzick, C Ryan, AJ Lenvik, KL Boylan, HC Wong, AP Skubitz, JS Miller, MA Geller
    Gynecol. Oncol, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Peripheral human CD4(+)CD8(+) T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15
    Authors: ML Clénet, F Gagnon, AC Moratalla, EC Viel, N Arbour
    Sci Rep, 2017;7(1):11612.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Rheumatoid arthritis bone marrow environment supports Th17 response
    Authors: E Kuca-Warna, W Kurowska, M Prochorec-, A Radzikowsk, T Burakowski, U Skalska, M Massalska, M Pleba?czyk, B Ma?dyk-Now, I S?owi?ska, R Gasik, W Ma?li?ski
    Arthritis Res. Ther., 2017;19(1):274.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
    Authors: JX Lin, N Du, P Li, M Kazemian, T Gebregiorg, R Spolski, WJ Leonard
    Nat Commun, 2017;8(1):1320.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Hydroxychloroquine inhibits CD154 expression in CD4(+) T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling
    Authors: SF Wu, CB Chang, JM Hsu, MC Lu, NS Lai, C Li, CH Tung
    Arthritis Res. Ther., 2017;19(1):183.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells
    Authors: M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney
    Clin. Cancer Res, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities
    Authors: Y Van Caeneg, S De Munter, P Tieppo, G Goetgeluk, K Weening, G Verstichel, S Bonte, T Taghon, G Leclercq, T Kerre, R Debets, D Vermijlen, H Abken, B Vandekerck
    Oncoimmunology, 2017;6(3):e1283460.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes
    Authors: Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang
    Am J Transl Res, 2017;9(2):454-465.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells
    Authors: W Li, Y Wu, D Kong, H Yang, Y Wang, J Shao, Y Feng, W Chen, L Ma, T Ying, DS Dimitrov
    Sci Rep, 2017;7(1):9130.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors
    Authors: C Gavegnano, JH Brehm, FP Dupuy, A Talla, SP Ribeiro, DA Kulpa, C Cameron, S Santos, SJ Hurwitz, VC Marconi, JP Routy, L Sabbagh, RF Schinazi, RP Sékaly
    PLoS Pathog., 2017;13(12):e1006740.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Rheumatoid arthritis bone marrow environment supports Th17 response.
    Authors: Ewa Kuca-Warna, Weronika Kurowska, Monika Prochorec, Anna Radzikows, Tomasz Burakowsk, Urszula Skalska, Magdalena Massalska, Magdalena Pleba?czy, Barbara Ma?dyk-No, Iwona S?owi?ska, Robert Gasik, W?odzimierz Ma?li?ski
    Arthritis Research & Therapy, 2017;0(0):1478-6362.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Clinical and immunological responses after CD30-specific chimeric antigen receptor-redirected lymphocytes
    Authors: CA Ramos, B Ballard, H Zhang, O Dakhova, AP Gee, Z Mei, M Bilgi, MF Wu, H Liu, B Grilley, CM Bollard, BH Chang, CM Rooney, MK Brenner, HE Heslop, G Dotti, B Savoldo
    J. Clin. Invest., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis
    Authors: Anja Kerstein
    J. Autoimmun, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes
    Authors: RB Jones, S Mueller, R O'Connor, K Rimpel, DD Sloan, D Karel, HC Wong, EK Jeng, AS Thomas, JB Whitney, SY Lim, C Kovacs, E Benko, S Karandish, SH Huang, MJ Buzon, M Lichterfel, A Irrinki, JP Murry, A Tsai, H Yu, R Geleziunas, A Trocha, MA Ostrowski, Irvi
    PLoS Pathog, 2016;12(4):e1005545.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection
    Authors: Souheil-Antoine Younes
    J Clin Invest, 2016;126(7):2745-2756.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation.
    Authors: Isabela Pedroza-Pa, Divya Shah, Anna Domogala, Martha Luevano, Michael Blundell, Nicola Jackson, Adrian Thrasher, Alejandro Madrigal, Aurore Saudemont
    Scientific Reports, 2016;0(0):2045-2322.
    Species: Xenograft
    Sample Types: In Vivo
    Applications: In Vivo
  53. CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes
    Sci Rep, 2016;6(0):34310.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo
    PLoS Pathog, 2016;12(8):e1005788.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia
    Mol Ther, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: CAR-T (Bioassay)
  56. Novel chemoimmunotherapeutic strategy for hepatocellular carcinoma based on a genome-wide association study
    Sci Rep, 2016;6(0):38407.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM)
    Oncotarget, 2016;0(0):.
    Species: Mouse
    Sample Types:
    Applications: In Vivo
  58. Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance
    Oncoimmunology, 2016;5(6):e1165376.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Efficient regeneration of Human V?24(+) invariant NKT cells and their anti-tumor activity in vivo
    Stem Cells, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
    Authors: Vesna Pulko
    Nat Immunol, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. IL-15 amplifies the pathogenic properties of CD4+CD28- T cells in multiple sclerosis.
    Authors: Broux B, Mizee M, Vanheusden M, van der Pol S, van Horssen J, Van Wijmeersch B, Somers V, de Vries H, Stinissen P, Hellings N
    J Immunol, 2015;194(5):2099-109.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Ralpha treatment.
    Authors: Nair S, Fang M, Sigal L
    Aging Cell, 2015;14(2):180-90.
    Species: Mouse
    Sample Types:
    Applications: In Vivo
  63. Survivin-specific T cell receptor targets tumor but not T cells.
    Authors: Arber C, Feng X, Abhyankar H, Romero E, Wu M, Heslop H, Barth P, Dotti G, Savoldo B
    J Clin Invest, 2015;125(1):157-68.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Effect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial.
    Authors: Bruckner S, Agnandji S, Berberich S, Bache E, Fernandes J, Schweiger B, Massinga Loembe M, Engleitner T, Lell B, Mordmuller B, Adegnika A, Yazdanbakhsh M, Kremsner P, Esen M
    PLoS Negl Trop Dis, 2015;9(6):e0003768.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Evidence for eomesodermin-expressing innate-like CD8(+) KIR/NKG2A(+) T cells in human adults and cord blood samples.
    Authors: Jacomet F, Cayssials E, Basbous S, Levescot A, Piccirilli N, Desmier D, Robin A, Barra A, Giraud C, Guilhot F, Roy L, Herbelin A, Gombert J
    Eur J Immunol, 2015;45(7):1926-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Ralpha production.
    Authors: Yokota S, Yoshida O, Dou L, Spadaro A, Isse K, Ross M, Stolz D, Kimura S, Du Q, Demetris A, Thomson A, Geller D
    J Immunol, 2015;194(12):6045-56.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  67. Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice.
    Authors: Thomas S, Klobuch S, Podlech J, Plachter B, Hoffmann P, Renzaho A, Theobald M, Reddehase M, Herr W, Lemmermann N
    PLoS Pathog, 2015;11(7):e1005049.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.
    Authors: Lam, Sharon, Sung, Julia, Cruz, Conrad, Castillo-Caro, Paul, Ngo, Minhtran, Garrido, Carolina, Kuruc, Joann, Archin, Nancie, Rooney, Cliona, Margolis, David, Bollard, Catherin
    Mol Ther, 2015;23(2):387-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells.
    Authors: Mongini P, Gupta R, Boyle E, Nieto J, Lee H, Stein J, Bandovic J, Stankovic T, Barrientos J, Kolitz J, Allen S, Rai K, Chu C, Chiorazzi N
    J Immunol, 2015;195(3):901-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Mature cytotoxic CD56(bright)/CD16(+) natural killer cells can infiltrate lymph nodes adjacent to metastatic melanoma.
    Cancer Res, 2015;74(0):81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Ex vivo cytosolic delivery of functional macromolecules to immune cells.
    Authors: Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos G, Eyerman A, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan O, Addo M, von Andrian U, Anderson D, Langer R, Lieberman J, Jensen K
    PLoS ONE, 2015;10(4):e0118803.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Concurrent interaction of DCs with CD4(+) and CD8(+) T cells improves secondary CTL expansion: It takes three to tango.
    Authors: Hoyer S, Prommersberger S, Pfeiffer I, Schuler-Thurner B, Schuler G, Dorrie J, Schaft N
    Eur J Immunol, 2014;44(12):3543-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis.
    Authors: Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V
    J Allergy Clin Immunol, 2014;134(2):373-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Human AdV-specific T cells: persisting in vitro functionality despite lethal irradiation.
    Authors: Geyeregger R, Freimuller C, Stemberger J, Fischer G, Witt V, Fritsch G
    Bone Marrow Transplant, 2014;49(7):934-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Regulation of CD4(+)NKG2D(+) Th1 cells in patients with metastatic melanoma treated with sorafenib: role of IL-15Ralpha and NKG2D triggering.
    Authors: Romero A, Chaput N, Poirier-Colame V, Rusakiewicz S, Jacquelot N, Chaba K, Mortier E, Jacques Y, Caillat-Zucman S, Flament C, Caignard A, Messaoudene M, Auperin A, Vielh P, Dessen P, Porta C, Mateus C, Ayyoub M, Valmori D, Eggermont A, Robert C, Zitvogel L
    Cancer Res, 2014;74(1):68-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.
    Authors: Li H, Richert-Spuhler L, Evans T, Gillis J, Connole M, Estes J, Keele B, Klatt N, Reeves R
    PLoS Pathog, 2014;10(12):e1004551.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Defective expression of scavenger receptors in celiac disease mucosa.
    Authors: Cupi M, Sarra M, De Nitto D, Franze E, Marafini I, Monteleone I, Del Vecchio Blanco G, Paoluzi O, Di Fusco D, Gentileschi P, Ortenzi A, Colantoni A, Pallone F, Monteleone G
    PLoS ONE, 2014;9(6):e100980.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. The IL-23/Th17 axis is involved in the adaptive immune response to Bacillus anthracis in humans.
    Authors: Harris K, Ramachandran G, Basu S, Rollins S, Mann D, Cross A
    Eur J Immunol, 2014;44(3):752-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Tumor-activated TCRgammadelta(+) T cells from gastric cancer patients induce the antitumor immune response of TCRalphabeta(+) T cells via their antigen-presenting cell-like effects.
    Authors: Mao C, Mou X, Zhou Y, Yuan G, Xu C, Liu H, Zheng T, Tong J, Wang S, Chen D
    J Immunol Res, 2014;2014(0):593562.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies.
    Authors: Bojarczuk K, Siernicka M, Dwojak M, Bobrowicz M, Pyrzynska B, Gaj P, Karp M, Giannopoulos K, Efremov D, Fauriat C, Golab J, Winiarska M
    Leukemia, 2014;28(5):1163-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals.
    Authors: Bastidas S, Graw F, Smith M, Kuster H, Gunthard H, Oxenius A
    J Immunol, 2014;192(4):1732-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection.
    Authors: Golden-Mason L, Hahn Y, Strong M, Cheng L, Rosen H
    PLoS ONE, 2014;9(7):e103219.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections.
    Authors: Banu, Nasirah, Chia, Adeline, Ho, Zi Zong, Garcia, Alfonso, Paravasivam, Komathi, Grotenbreg, Gijsbert, Bertoletti, Antonio, Gehring, Adam J
    Sci Rep, 2014;4(0):4166.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter.
    Authors: Lowe R, Genin A, Orgun N, Cron R
    Genes Immun, 2014;15(3):137-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Reversal of tumor immune inhibition using a chimeric cytokine receptor.
    Authors: Leen A, Sukumaran S, Watanabe N, Mohammed S, Keirnan J, Yanagisawa R, Anurathapan U, Rendon D, Heslop H, Rooney C, Brenner M, Vera J
    Mol Ther, 2014;22(6):1211-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.
    Authors: Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K
    J Immunol, 2014;193(5):2297-305.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Wilms' Tumour 1 (WT1) peptide vaccination in patients with acute myeloid leukaemia induces short-lived WT1-specific immune responses.
    Authors: Uttenthal B, Martinez-Davila I, Ivey A, Craddock C, Chen F, Virchis A, Kottaridis P, Grimwade D, Khwaja A, Stauss H, Morris E
    Br J Haematol, 2014;164(3):366-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. IL-15 positively regulates IL-21 production in celiac disease mucosa.
    Authors: Sarra M, Cupi M, Monteleone I, Franze E, Ronchetti G, Di Sabatino A, Gentileschi P, Franceschilli L, Sileri P, Sica G, Del Vecchio Blanco G, Cretella M, Paoluzi O, Corazza G, Pallone F, Monteleone G
    Mucosal Immunol, 2013;6(2):244-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. PaCS is a novel cytoplasmic structure containing functional proteasome and inducible by cytokines/trophic factors.
    Authors: Sommi, Patrizia, Necchi, Vittorio, Vitali, Agostina, Montagna, Daniela, De Luigi, Ada, Salmona, Mario, Ricci, Vittorio, Solcia, Enrico
    PLoS ONE, 2013;8(12):e82560.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  90. Short-term in-vitro expansion improves monitoring and allows affordable generation of virus-specific T-cells against several viruses for a broad clinical application.
    Authors: Geyeregger R, Freimuller C, Stevanovic S, Stemberger J, Mester G, Dmytrus J, Lion T, Rammensee H, Fischer G, Eiz-Vesper B, Lawitschka A, Matthes S, Fritsch G
    PLoS ONE, 2013;8(4):e59592.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. GITR-dependent regulation of 4-1BB expression: implications for T cell memory and anti-4-1BB-induced pathology.
    Authors: Lin G, Snell L, Wortzman M, Clouthier D, Watts T
    J Immunol, 2013;190(9):4627-39.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Immunoregulatory pathways are active in the small intestinal mucosa of patients with potential celiac disease.
    Authors: Borrelli M, Salvati V, Maglio M, Zanzi D, Ferrara K, Santagata S, Ponticelli D, Aitoro R, Mazzarella G, Lania G, Gianfrani C, Auricchio R, Troncone R
    Am J Gastroenterol, 2013;108(11):1775-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes.
    Authors: Dong J, Chang H, Ivascu C, Qian Y, Rezai S, Okhrimenko A, Cosmi L, Maggi L, Eckhardt F, Wu P, Sieper J, Alexander T, Annunziato F, Gossen M, Li J, Radbruch A, Thiel A
    Eur J Immunol, 2013;43(3):793-804.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. CCR5 is a receptor for Staphylococcus aureus leukotoxin ED.
    Authors: Alonzo, Francis, Kozhaya, Lina, Rawlings, Stephen, Reyes-Robles, Tamara, DuMont, Ashley L, Myszka, David G, Landau, Nathanie, Unutmaz, Derya, Torres, Victor J
    Nature, 2013;493(7430):51-5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  95. The microenvironment of human neuroblastoma supports the activation of tumor-associated T lymphocytes.
    Authors: Carlson L, De Geer A, Sveinbjornsson B, Orrego A, Martinsson T, Kogner P, Levitskaya J
    Oncoimmunology, 2013;2(3):e23618.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells.
    Authors: Ichii, Michiko, Frank, Mark Bar, Iozzo, Renato V, Kincade, Paul W
    Blood, 2012;119(7):1683-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.
    Authors: Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S
    PLoS Pathog., 2012;8(1):e1002486.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Antigen-independent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway.
    Authors: Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA
    J. Immunol., 2012;188(8):3745-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. 2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation.
    Authors: Andresen L, Skovbakke SL, Persson G, Hagemann-Jensen M, Hansen KA, Jensen H, Skov S
    J. Immunol., 2012;188(4):1847-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  100. IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression.
    Authors: Milpied P, Massot B, Renand A, Diem S, Herbelin A, Leite-de-Moraes M, Rubio MT, Hermine O
    Blood, 2011;118(11):2993-3002.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity.
    Authors: Mamessier E, Sylvain A, Thibult ML, Houvenaeghel G, Jacquemier J, Castellano R, Goncalves A, Andre P, Romagne F, Thibault G, Viens P, Birnbaum D, Bertucci F, Moretta A, Olive D
    J. Clin. Invest., 2011;121(9):3609-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Natural killer cell-mediated cytokine response among HIV-positive south Indians with pulmonary tuberculosis.
    Authors: Ramana Rao PV, Rajasekaran S, Raja A
    J. Interferon Cytokine Res., 2010;30(1):33-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response.
    Authors: Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM
    J. Immunol., 2010;185(11):6646-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Barley as a green factory for the production of functional Flt3 ligand.
    Authors: Erlendsson LS, Muench MO, Hellman U, Hrafnkelsdottir SM, Jonsson A, Balmer Y, Mantyla E, Orvar BL
    Biotechnol J, 2010;5(2):163-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages.
    Authors: Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, Ponsoda S, Delneste Y, Hebbar M, Jeannin P
    Int. J. Cancer, 2009;125(2):367-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge.
    Authors: Kwant-Mitchell A, Pek EA, Rosenthal KL
    PLoS ONE, 2009;4(12):e8379.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium.
    Authors: Kitaya K, Yasuo T
    J. Leukoc. Biol., 2009;85(3):391-400.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15.
    Authors: Giron-Michel J, Menard F, Negrini S, Devocelle A, Azzarone B, Besson C
    Blood, 2009;113(19):4541-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
    Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
    Circulation, 2009;119(10):1424-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15.
    Authors: McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS
    Exp. Hematol., 2008;36(5):598-608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. CD27 defines phenotypically and functionally different human NK cell subsets.
    Authors: Vossen MT, Matmati M, Hertoghs KM, Baars PA, Gent MR, Leclercq G, Hamann J, Kuijpers TW, van Lier RA
    J. Immunol., 2008;180(6):3739-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15.
    Authors: Bulanova E, Budagian V, Duitman E, Orinska Z, Krause H, Ruckert R, Reiling N, Bulfone-Paus S
    J. Biol. Chem., 2007;282(18):13167-79.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
    Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
    Blood, 2007;109(10):4272-9.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  114. Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays.
    Authors: Pfleger C, Schloot N, ter Veld F
    J. Immunol. Methods, 2007;329(1):214-8.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  115. Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion.
    Authors: de Matos CT, Berg L, Michaelsson J, Fellander-Tsai L, Karre K, Soderstrom K
    Immunology, 2007;122(2):291-301.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.
    Authors: Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS
    J. Immunol., 2006;177(7):4488-94.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  117. A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo.
    Authors: von Strandmann EP, Hansen HP, Reiners KS, Schnell R, Borchmann P, Merkert S, Simhadri VR, Draube A, Reiser M, Purr I, Hallek M, Engert A
    Blood, 2006;107(5):1955-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.
    Authors: Ebert EC, Mehta V
    Cell. Immunol., 2006;241(1):7-13.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression.
    Authors: Cho ML, Min SY, Chang SH, Kim KW, Heo SB, Lee SH, Park SH, Cho CS, Kim HY
    Immunol. Lett., 2006;105(2):159-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Bovine splenic NK cells synthesize IFN-gamma in response to IL-12-containing supernatants from Babesia bovis-exposed monocyte cultures.
    Authors: Goff WL, Storset AK, Johnson WC, Brown WC
    Parasite Immunol., 2006;28(5):221-8.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL).
    Authors: Hanabuchi S, Watanabe N, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ
    Blood, 2006;107(9):3617-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes.
    Authors: Eidenschenk C, Jouanguy E, Alcais A, Mention JJ, Pasquier B, Fleckenstein IM, Puel A, Gineau L, Carel JC, Vivier E, Le Deist F, Casanova JL
    J. Immunol., 2006;177(12):8835-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells.
    Authors: Alves NL, Arosa FA, van Lier RA
    J. Immunol., 2005;175(2):755-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism.
    Authors: Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D
    J. Immunol., 2005;174(4):2376-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Renal cells express a functional interleukin-15 receptor.
    Authors: Tejman-Yarden N, Zlotnik M, Lewis E, Etzion O, Chaimovitz C, Douvdevani A
    Nephrol. Dial. Transplant., 2005;20(3):516-23.
    Species: N/A
    Sample Types: N/A
    Applications: Western Blot
  126. The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing.
    Authors: Conklyn M, Andresen C, Changelian P, Kudlacz E
    J. Leukoc. Biol., 2004;76(6):1248-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Growth and apoptosis of human natural killer cell neoplasms: role of interleukin-2/15 signaling.
    Authors: Yamasaki S, Maeda M, Ohshima K, Kikuchi M, Otsuka T, Harada M
    Leuk. Res., 2004;28(10):1023-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004;173(5):3482-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Expression and activity of IL-17 in cutaneous T-cell lymphomas (mycosis fungoides and Sezary syndrome).
    Authors: Ciree A, Michel L, Camilleri-Broet S, Jean Louis F, Oster M, Flageul B, Senet P, Fossiez F, Fridman WH, Tartour E
    Int. J. Cancer, 2004;112(1):113-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. IL-21 induces the functional maturation of murine NK cells.
    Authors: Brady J, Hayakawa Y, Smyth MJ, Nutt SL
    J. Immunol., 2004;172(4):2048-58.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Regulation of CCR5 expression and MIP-1alpha production in CD4+ T cells from patients with rheumatoid arthritis.
    Authors: Wang CR, Liu MF
    Clin. Exp. Immunol., 2003;132(2):371-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis.
    Authors: Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T
    Proc. Natl. Acad. Sci. U.S.A., 2003;100(16):9452-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Use of interleukin 15 to enhance interferon-gamma production by antigen-specific stimulated lymphocytes from rhesus macaques.
    Authors: Calarota SA, Otero M, Hermanstayne K, Lewis M, Rosati M, Felber BK, Pavlakis GN, Boyer JD, Weiner DB
    J. Immunol. Methods, 2003;279(1):55-67.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis.
    Authors: Ong PY, Hamid QA, Travers JB, Strickland I, Al Kerithy M, Boguniewicz M, Leung DY
    J. Immunol., 2002;168(1):505-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  135. Restoration of cytotoxic T lymphocyte function in malignant pleural effusion: interleukin-15 vs. interleukin-2.
    Authors: Chen YM, Ting CC, Peng JW, Yang WK, Yang KY, Tsai CM, Perng RP
    J. Interferon Cytokine Res., 2000;20(1):31-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Human amniotic fluid lacks interleukin-2 and interleukin-15 but can interact with the beta-chain of the interleukin-2 receptor.
    Authors: Searle RF, Bromage SJ, Palmer J, Curry JE, Lang AK
    Immunology, 2000;99(3):411-7.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  137. Dendritic Cell-Derived IL-32alpha: A Novel Inhibitory Cytokine of NK Cell Function.
    Authors: Gorvel L, Korenfeld D, Tung T, Klechevsky E
    J Immunol, 0;199(4):1290-1300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  138. CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma.
    Authors: Heczey A, Louis C, Savoldo B, Dakhova O, Durett A, Grilley B, Liu H, Wu M, Mei Z, Gee A, Mehta B, Zhang H, Mahmood N, Tashiro H, Heslop H, Dotti G, Rooney C, Brenner M
    Mol Ther, 0;25(9):2214-2224.
    Species: Human
    Sample Types: Whole Cells
    Applications: CAR-T (Bioassay)

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Recombinant Human IL-15 Protein
By Anonymous on 06/11/2019
Application: In vitro bioactivity in cell culture

Recombinant Human IL-15 Protein
By Anonymous on 10/08/2018
Application: In vitro bioactivity in cell culture

Recombinant Human IL-15 Protein
By Anonymous on 11/20/2017
Application: Immunoassay Standard

The IL15 protein was used as a control and standard for an ELISA using MAB647 and BAM247 as the matched pair.